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5.76 Tc /F1 8.0 Tf 1 0 0 1 114.72 432.00 Tm <9378> Tj 1 0 0 1 123.84 433.20 Tm <82CC> Tj 1 0 0 1 131.52 432.24 Tm <8CF5> Tj 1 0 0 1 139.68 432.48 Tm <8FC6> Tj 1 0 0 1 148.32 432.48 Tm <8ECB> Tj 1 0 0 1 157.68 433.20 Tm <82C9> Tj 1 0 0 1 167.04 433.20 Tm <82E6> Tj 1 0 0 1 175.68 433.20 Tm <82C1> Tj 1 0 0 1 183.36 433.44 Tm <82C4> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 193.44 433.44 Tm <49504D82CC> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 221.28 432.72 Tm <8CF5> Tj 1 0 0 1 229.92 432.72 Tm <899E> Tj 1 0 0 1 238.80 432.72 Tm <939A> Tj 1 0 0 1 43.44 419.28 Tm <82CC> Tj 1 0 0 1 51.36 418.32 Tm <88D9> Tj 1 0 0 1 59.76 418.32 Tm <8FED> Tj 1 0 0 1 68.40 419.28 Tm <82AA> Tj 1 0 0 1 76.32 418.56 Tm <8B4E> Tj 1 0 0 1 86.40 419.76 Tm <82B1> Tj 1 0 0 1 95.76 419.04 Tm <82E8> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 102.48 418.32 Tm <2C8E8B> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 119.52 418.80 Tm <8DD7> Tj 1 0 0 1 127.68 418.80 Tm <9645> Tj 1 0 0 1 136.32 418.80 Tm <95CF> Tj 1 0 0 1 144.72 419.04 Tm <90AB> Tj 1 0 0 1 153.60 419.76 Tm <82AA> Tj 1 0 0 1 162.24 419.04 Tm <88F8> Tj 1 0 0 1 172.08 419.04 Tm <82AB> Tj 1 0 0 1 179.28 419.04 Tm <8B4E> Tj 1 0 0 1 189.12 420.24 Tm <82B1> Tj 1 0 0 1 197.28 419.52 Tm <82B3> Tj 1 0 0 1 204.72 419.52 Tm <82EA> Tj 1 0 0 1 213.36 420.00 Tm <82C4> Tj 1 0 0 1 222.00 420.24 Tm <82A2> Tj 1 0 0 1 231.12 419.76 Tm <82E9> Tj 1 0 0 1 238.80 419.52 Tm <89C2> Tj 1 0 0 1 42.96 404.88 Tm <945C> Tj 1 0 0 1 51.60 404.88 Tm <90AB> Tj 1 0 0 1 60.24 405.84 Tm <82AA> Tj 1 0 0 1 68.64 405.12 Tm <82A0> Tj 1 0 0 1 77.52 405.60 Tm <82E9> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 84.96 405.12 Tm <2E82BB> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 103.92 406.32 Tm <82B1> Tj 1 0 0 1 111.36 406.08 Tm <82C5> Tj 1 0 0 1 119.76 405.36 Tm <967B> Tj 1 0 0 1 127.92 405.36 Tm <8CA4> Tj 1 0 0 1 136.32 405.60 Tm <8B86> Tj 1 0 0 1 145.20 406.08 Tm <82C9> Tj 1 0 0 1 153.84 406.32 Tm <82A8> Tj 1 0 0 1 162.72 406.56 Tm <82A2> Tj 1 0 0 1 171.36 406.32 Tm <82C4> Tj 1 0 0 1 180.00 406.56 Tm <82CD> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 187.92 405.60 Tm <2C89DF> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 204.48 405.60 Tm <9378> Tj 1 0 0 1 213.36 406.56 Tm <82CC> Tj 1 0 0 1 221.52 405.60 Tm <8CF5> Tj 1 0 0 1 230.16 405.84 Tm <8FC6> Tj 1 0 0 1 239.04 406.08 Tm <8ECB> Tj 1 0 0 1 43.68 391.92 Tm <82F0> Tj 1 0 0 1 51.60 391.44 Tm <8ADC> Tj 1 0 0 1 60.00 392.40 Tm <82DF> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 68.16 391.44 Tm <2C90E6> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 85.68 392.64 Tm <82CC> Tj 1 0 0 1 94.08 391.68 Tm <95F1> Tj 1 0 0 1 102.96 391.68 Tm <8D90> Tj 0.00 Tc /F1 5.5 Tf 1 0 0 1 111.36 395.76 Tm <32292D342982E6> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 136.32 392.40 Tm <82E8> Tj 1 0 0 1 144.24 392.16 Tm <82E0> Tj 1 0 0 1 152.88 392.40 Tm <82B3> Tj 1 0 0 1 162.00 392.40 Tm <82E7> Tj 1 0 0 1 170.16 392.88 Tm <82C9> Tj 1 0 0 1 178.08 392.16 Tm <8DD7> Tj 1 0 0 1 187.44 393.12 Tm <82A9> Tj 1 0 0 1 197.28 392.40 Tm <82AD> Tj 1 0 0 1 203.76 392.16 Tm <8CF5> Tj 1 0 0 1 213.12 393.12 Tm <82CC> Tj 1 0 0 1 221.04 392.40 Tm <8FF0> Tj 1 0 0 1 229.92 392.40 Tm <8C8F> Tj 1 0 0 1 239.52 392.88 Tm <82F0> Tj 1 0 0 1 43.20 378.00 Tm <95CF> Tj 1 0 0 1 51.84 378.00 Tm <89BB> Tj 1 0 0 1 61.44 378.48 Tm <82B3> Tj 1 0 0 1 68.64 378.96 Tm <82B9> Tj 1 0 0 1 77.52 378.72 Tm <82BD> Tj 1 0 0 1 85.92 378.00 Tm <8FEA> Tj 1 0 0 1 95.04 378.24 Tm <8D87> Tj 1 0 0 1 104.40 379.20 Tm <82CC> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 114.48 378.96 Tm <49504D95AA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 142.56 378.48 Tm <957A> Tj 1 0 0 1 151.68 379.44 Tm <82CC> Tj 1 0 0 1 160.08 378.72 Tm <976C> Tj 1 0 0 1 168.96 378.72 Tm <8EAE> Tj 1 0 0 1 178.56 379.20 Tm <82C9> Tj 1 0 0 1 186.72 380.16 Tm <82C2> Tj 1 0 0 1 195.84 379.68 Tm <82A2> Tj 1 0 0 1 204.00 379.44 Tm <82C4> Tj 1 0 0 1 212.16 379.20 Tm <94E4> Tj 1 0 0 1 220.80 378.72 Tm <8A72> Tj 1 0 0 1 229.68 378.72 Tm <8C9F> Tj 1 0 0 1 239.28 378.72 Tm <93A2> Tj 1 0 0 1 44.64 365.04 Tm <82B5> Tj 1 0 0 1 51.84 365.28 Tm <82BD> Tj 1 0 0 1 60.00 364.32 Tm <8142> Tj 0.00 Tc /F1 12.5 Tf 1 0 0 1 114.00 344.64 Tm <494920> Tj 7.68 Tc /F1 9.5 Tf 1 0 0 1 133.68 343.68 Tm <8EC0> Tj 1 0 0 1 144.00 343.68 Tm <8CB1> Tj 1 0 0 1 155.04 343.92 Tm <95FB> Tj 1 0 0 1 166.08 344.16 Tm <9640> Tj /F1 8.0 Tf 1 0 0 1 52.80 324.00 Tm <9492> Tj 1 0 0 1 60.24 324.48 Tm <9046> Tj 1 0 0 1 68.40 324.24 Tm <90AC> Tj 1 0 0 1 76.80 324.24 Tm <8F6E> Tj 1 0 0 1 86.88 325.20 Tm <8389> Tj 1 0 0 1 96.24 324.96 Tm <8362> Tj 1 0 0 1 105.60 325.20 Tm <8367> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 113.52 324.48 Tm <28524353815D> Tj /F1 6.5 Tf 1 0 0 1 136.80 325.20 Tm <72647981A1> Tj /F1 10.0 Tf 1 0 0 1 158.40 325.20 Tm <3A388160> Tj /F1 7.5 Tf 1 0 0 1 181.20 325.44 Tm <31308F54> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 197.76 324.96 Tm <97EE> Tj 0.00 Tc /F1 8.5 Tf 1 0 0 1 205.92 324.96 Tm <2982F0> Tj /F1 10.5 Tf 1 0 0 1 220.32 324.72 Tm <2C96BE> Tj /F1 7.0 Tf 1 0 0 1 240.00 324.96 Tm <7B37> Tj /F1 12.0 Tf 1 0 0 1 43.20 311.28 Tm <414D8FC6> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 69.36 310.80 Tm <96BE> Tj 0.00 Tc /F1 10.0 Tf 1 0 0 1 79.44 311.28 Tm <6F6E3A436167659594> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 127.44 311.04 Tm <8FC6> Tj 1 0 0 1 135.60 310.80 Tm <9378> Tj 1 0 0 1 144.72 312.00 Tm <82CD> Tj 0.00 Tc /F1 6.5 Tf 1 0 0 1 152.64 311.76 Tm <323020666F6F74815D> Tj /F1 7.5 Tf 1 0 0 1 183.36 311.76 Tm <63616E646C65286674815D> Tj /F1 8.5 Tf 1 0 0 1 226.08 312.00 Tm <63297D3A> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 43.44 297.12 Tm <88C3> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 56.64 297.36 Tm <2837504D8FC6> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 90.24 297.36 Tm <96BE> Tj 0.00 Tc /F1 6.5 Tf 1 0 0 1 100.56 298.08 Tm <6F8167> Tj /F1 10.0 Tf 1 0 0 1 111.60 297.60 Tm <293D31323A31328E9E> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 158.64 297.60 Tm <8AD4> Tj 1 0 0 1 167.76 298.08 Tm <8EFC> Tj 1 0 0 1 176.64 297.84 Tm <8AFA> Tj 1 0 0 1 185.76 298.08 Tm <89BA> Tj 1 0 0 1 195.36 298.56 Tm <82C9> Tj 1 0 0 1 203.28 298.08 Tm <8E94> Tj 1 0 0 1 212.40 298.08 Tm <88E7> Tj 1 0 0 1 222.72 298.80 Tm <82B5> Tj 1 0 0 1 230.88 298.80 Tm <82BD> Tj 1 0 0 1 239.52 298.08 Tm <8142> Tj 1 0 0 1 44.88 284.64 Tm <8389> Tj 1 0 0 1 54.00 284.16 Tm <8362> Tj 1 0 0 1 62.88 284.64 Tm <8367> Tj 1 0 0 1 69.60 284.16 Tm <82F0> Tj 1 0 0 1 78.00 283.92 Tm <88C3> Tj 1 0 0 1 87.12 283.92 Tm <8F87> Tj 1 0 0 1 96.24 283.92 Tm <899E> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 110.16 283.92 Tm <2890E2> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 122.88 284.16 Tm <91CE> Tj 1 0 0 1 131.52 284.16 Tm <88C3> Tj 1 0 0 1 140.64 284.16 Tm <8EBA> Tj 0.00 Tc /F1 8.5 Tf 1 0 0 1 152.40 284.64 Tm <3A96E9> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 168.48 284.88 Tm <82C7> Tj 1 0 0 1 178.32 284.64 Tm <82A4> Tj 1 0 0 1 186.72 284.88 Tm <82B5> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 193.92 285.12 Tm <31328E9E> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 210.96 284.64 Tm <8AD4> Tj 0.00 Tc /F1 12.0 Tf 1 0 0 1 222.72 285.12 Tm <3A37414D> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 44.40 270.96 Tm <82C9> Tj 1 0 0 1 52.32 270.24 Tm <88C8> Tj 1 0 0 1 60.48 270.48 Tm <89BA> Tj 1 0 0 1 69.12 271.20 Tm <82CC> Tj 1 0 0 1 77.04 270.24 Tm <8EC0> Tj 1 0 0 1 85.44 270.24 Tm <8CB1> Tj 1 0 0 1 94.80 270.72 Tm <82F0> Tj 1 0 0 1 103.44 270.24 Tm <8A4A> Tj 1 0 0 1 111.84 270.48 Tm <8E6E> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 120.48 270.48 Tm <2982B3> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 136.80 271.68 Tm <82B9> Tj 1 0 0 1 145.44 271.20 Tm <82BD> Tj 1 0 0 1 153.84 270.72 Tm <8CE3> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 162.72 270.48 Tm <2C20378C51> Tj /F1 7.0 Tf 1 0 0 1 193.20 270.96 Tm <288A65> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 204.96 271.20 Tm <8C51> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 215.52 271.68 Tm <339543> Tj /F1 11.0 Tf 1 0 0 1 230.88 271.20 Tm <2982C9> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 44.16 256.56 Tm <95AA> Tj 1 0 0 1 52.80 256.80 Tm <82AF> Tj 0.00 Tc /F1 10.0 Tf 1 0 0 1 60.48 256.32 Tm <2C88C8> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 77.04 257.04 Tm <89BA> Tj 1 0 0 1 86.16 257.76 Tm <82CC> Tj 1 0 0 1 94.56 256.80 Tm <8CF5> Tj 1 0 0 1 102.96 256.80 Tm <8FF0> Tj 1 0 0 1 111.84 256.80 Tm <8C8F> Tj 1 0 0 1 120.96 257.76 Tm <82CC> Tj 1 0 0 1 130.08 257.28 Tm <82E0> Tj 1 0 0 1 138.48 257.76 Tm <82C6> Tj 1 0 0 1 145.92 257.76 Tm <82C9> Tj 1 0 0 1 153.60 257.04 Tm <9259> Tj 1 0 0 1 162.72 257.04 Tm <8E5F> Tj 1 0 0 1 172.80 258.24 Tm <834B> Tj 1 0 0 1 180.96 258.72 Tm <8358> Tj 1 0 0 1 189.12 257.76 Tm <82F0> Tj 1 0 0 1 197.28 257.52 Tm <8B7A> Tj 1 0 0 1 205.44 257.28 Tm <88F8> Tj 1 0 0 1 214.80 258.00 Tm <82B3> Tj 1 0 0 1 222.24 258.48 Tm <82B9> Tj 1 0 0 1 231.84 258.24 Tm <82E9> Tj 1 0 0 1 240.96 258.72 Tm <82B1> Tj 1 0 0 1 45.36 243.60 Tm <82C6> Tj 1 0 0 1 52.80 243.84 Tm <82C9> Tj 1 0 0 1 61.68 244.08 Tm <82E6> Tj 1 0 0 1 69.84 243.84 Tm <82C1> Tj 1 0 0 1 77.52 244.08 Tm <82C4> Tj 1 0 0 1 85.44 243.36 Tm <88C0> Tj 1 0 0 1 94.56 243.36 Tm <8A79> Tj 1 0 0 1 103.20 243.60 Tm <8E80> Tj 1 0 0 1 113.28 244.08 Tm <82B3> Tj 1 0 0 1 120.48 244.32 Tm <82B9> Tj 1 0 0 1 129.12 244.32 Tm <82BD> Tj 0.00 Tc /F1 11.5 Tf 1 0 0 1 137.04 243.60 Tm <2E312988C3> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 167.28 243.84 Tm <8F87> Tj 1 0 0 1 175.68 243.84 Tm <899E> Tj 1 0 0 1 185.04 244.32 Tm <82F0> Tj 1 0 0 1 192.96 244.08 Tm <8C70> Tj 1 0 0 1 201.12 244.08 Tm <91B1> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 209.52 243.84 Tm <2C322996BE> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 239.76 244.32 Tm <8F87> Tj 1 0 0 1 43.68 229.68 Tm <899E> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 54.72 229.92 Tm <28436167659594> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 88.32 229.92 Tm <8FC6> Tj 1 0 0 1 97.20 229.92 Tm <9378> Tj 1 0 0 1 106.32 230.88 Tm <82CD> Tj 0.00 Tc /F1 5.0 Tf 1 0 0 1 114.48 230.64 Tm <35306674815D> Tj /F1 12.0 Tf 1 0 0 1 131.52 230.64 Tm <633A37414D8FC6> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 175.68 230.40 Tm <96BE> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 186.00 230.88 Tm <6F6E29312C20352C31302C> Tj /F1 9.0 Tf 1 0 0 1 44.16 216.72 Tm <31352C333095AA> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 77.04 216.24 Tm <8CE3> Tj 0.00 Tc /F1 11.5 Tf 1 0 0 1 85.92 216.24 Tm <2C332989DF> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 116.16 216.48 Tm <9378> Tj 1 0 0 1 125.28 217.44 Tm <82CC> Tj 1 0 0 1 132.96 216.48 Tm <8CF5> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 145.92 216.72 Tm <288FC6> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 158.40 216.48 Tm <9378> Tj 1 0 0 1 167.76 217.68 Tm <82CD> Tj 0.00 Tc /F1 5.5 Tf 1 0 0 1 175.68 217.44 Tm <3530306674815D> Tj /F1 9.5 Tf 1 0 0 1 197.28 217.44 Tm <63298FC6> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 218.16 216.96 Tm <8ECB> Tj 0.00 Tc 1 0 0 1 227.04 217.68 Tm <313095AA> Tj /F1 2.5 Tf 1 0 0 1 244.32 216.96 Tm <2E> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 43.92 202.56 Tm <90E6> Tj 1 0 0 1 53.04 203.52 Tm <82C9> Tj 1 0 0 1 60.48 202.80 Tm <95F1> Tj 1 0 0 1 68.88 202.80 Tm <8D90> Tj 1 0 0 1 78.72 203.52 Tm <82B5> Tj 1 0 0 1 86.16 203.52 Tm <82BD> Tj 1 0 0 1 94.56 203.04 Tm <95FB> Tj 1 0 0 1 103.44 203.04 Tm <9640> Tj 0.00 Tc /F1 4.0 Tf 1 0 0 1 111.84 206.88 Tm <32298160> Tj /F1 6.0 Tf 1 0 0 1 121.20 206.88 Tm <342982C9> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 134.40 203.04 Tm <8F5D> Tj 1 0 0 1 144.00 204.00 Tm <82C1> Tj 1 0 0 1 151.68 204.00 Tm <82C4> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 160.08 203.04 Tm <2C8CC5> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 175.44 203.28 Tm <92E8> Tj 1 0 0 1 183.84 203.28 Tm <8974> Tj 1 0 0 1 193.20 204.24 Tm <82C9> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 200.64 204.24 Tm <322E3525676C75746172815C> Tj /F1 9.0 Tf 1 0 0 1 44.16 189.84 Tm <616C6465687964652C20322570617261664F726D616C64656879646528302E6C4D2070686F737068617465> Tj /F1 7.0 Tf 1 0 0 1 43.68 176.40 Tm <62758167> Tj /F1 9.0 Tf 1 0 0 1 59.04 176.40 Tm <65722C704820372E332C3337818E> Tj /F1 7.5 Tf 1 0 0 1 124.32 176.16 Tm <2982F0> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 137.28 176.16 Tm <8E67> Tj 1 0 0 1 145.68 176.16 Tm <9770> Tj 1 0 0 1 155.76 176.88 Tm <82B5> Tj 1 0 0 1 163.44 177.12 Tm <82C4> Tj 1 0 0 1 171.84 176.40 Tm <92BC> Tj 1 0 0 1 180.96 177.12 Tm <82BF> Tj 1 0 0 1 189.60 177.12 Tm <82C9> Tj 1 0 0 1 198.72 177.36 Tm <8389> Tj 1 0 0 1 207.60 177.12 Tm <8362> Tj 1 0 0 1 216.72 177.36 Tm <8367> Tj 1 0 0 1 222.96 176.88 Tm <82F0> Tj 1 0 0 1 231.12 176.40 Tm <9FF3> Tj 1 0 0 1 240.00 176.64 Tm <97AC> Tj 1 0 0 1 44.40 162.24 Tm <8CC5> Tj 1 0 0 1 52.56 162.24 Tm <92E8> Tj 1 0 0 1 62.40 162.96 Tm <82B5> Tj 1 0 0 1 69.36 162.96 Tm <82BD> Tj 1 0 0 1 77.52 162.24 Tm <8142> Tj 1 0 0 1 85.68 162.24 Tm <9FF3> Tj 1 0 0 1 94.80 162.48 Tm <97AC> Tj 1 0 0 1 103.92 162.72 Tm <8CC5> Tj 1 0 0 1 112.32 162.48 Tm <92E8> Tj 1 0 0 1 121.20 163.44 Tm <82CC> Tj 1 0 0 1 129.12 162.72 Tm <8AD4> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 137.52 162.48 Tm <2C82B8> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 155.52 163.44 Tm <82C1> Tj 1 0 0 1 164.88 163.44 Tm <82C6> Tj 1 0 0 1 172.32 163.20 Tm <82BB> Tj 1 0 0 1 180.72 163.20 Tm <82EA> Tj 1 0 0 1 189.12 163.20 Tm <82BC> Tj 1 0 0 1 197.76 163.20 Tm <82EA> Tj 1 0 0 1 205.44 162.96 Tm <88C0> Tj 1 0 0 1 214.08 162.96 Tm <8A79> Tj 1 0 0 1 222.72 163.20 Tm <8E80> Tj 1 0 0 1 231.12 163.20 Tm <914F> Tj 1 0 0 1 241.68 163.68 Tm <82C6> Tj 1 0 0 1 44.64 148.80 Tm <93AF> Tj 1 0 0 1 54.00 149.28 Tm <82B6> Tj 1 0 0 1 60.96 148.56 Tm <8CF5> Tj 1 0 0 1 69.12 148.80 Tm <8FF0> Tj 1 0 0 1 77.52 148.80 Tm <8C8F> Tj 1 0 0 1 86.64 149.28 Tm <82F0> Tj 1 0 0 1 94.80 148.80 Tm <88DB> Tj 1 0 0 1 103.68 149.04 Tm <8E9D> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 117.12 149.04 Tm <2893AA> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 129.12 149.28 Tm <9594> Tj 1 0 0 1 138.00 149.52 Tm <82F0> Tj 1 0 0 1 145.92 149.28 Tm <8D95> Tj 1 0 0 1 154.56 149.52 Tm <9046> Tj 1 0 0 1 164.16 150.24 Tm <8365> Tj 1 0 0 1 173.04 150.72 Tm <815B> Tj 1 0 0 1 181.68 150.48 Tm <8376> Tj 1 0 0 1 189.36 150.24 Tm <82C5> Tj 1 0 0 1 197.52 149.52 Tm <94ED> Tj 1 0 0 1 205.68 149.52 Tm <95A2> Tj 1 0 0 1 214.80 149.52 Tm <82A0> Tj 1 0 0 1 223.68 150.24 Tm <82E9> Tj 1 0 0 1 232.08 150.48 Tm <82A2> Tj 1 0 0 1 240.72 150.48 Tm <82CD> Tj 1 0 0 1 44.16 135.12 Tm <8CF5> Tj 1 0 0 1 53.04 135.84 Tm <82F0> Tj 1 0 0 1 60.96 135.36 Tm <8FC6> Tj 1 0 0 1 69.36 135.36 Tm <8ECB> Tj 0.00 Tc /F1 10.0 Tf 1 0 0 1 77.76 135.36 Tm <2982B5> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 95.28 136.32 Tm <82BD> Tj 1 0 0 1 103.68 135.36 Tm <8142> Tj 1 0 0 1 112.56 135.84 Tm <8AE1> Tj 1 0 0 1 120.96 135.60 Tm <8BF5> Tj 1 0 0 1 129.60 135.84 Tm <93E0> Tj 1 0 0 1 137.52 135.84 Tm <9765> Tj 1 0 0 1 145.92 135.84 Tm <8F9C> Tj 1 0 0 1 154.56 136.08 Tm <8B8E> Tj 1 0 0 1 163.92 136.32 Tm <82F0> Tj 1 0 0 1 172.32 135.84 Tm <8D73> Tj 1 0 0 1 181.44 137.04 Tm <82A2> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 189.12 135.84 Tm <2C8AE1> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 205.68 136.08 Tm <8B85> Tj 1 0 0 1 214.80 136.56 Tm <82F0> Tj 1 0 0 1 222.72 136.80 Tm <88EA> Tj 1 0 0 1 231.60 136.08 Tm <94D3> Tj 1 0 0 1 241.68 136.80 Tm <82B3> Tj 1 0 0 1 45.84 122.16 Tm <82E7> Tj 1 0 0 1 54.72 122.64 Tm <82C9> Tj 1 0 0 1 64.32 121.92 Tm <93AF> Tj 1 0 0 1 73.92 121.92 Tm <8CC5> Tj 1 0 0 1 83.28 122.16 Tm <92E8> Tj 1 0 0 1 93.60 121.92 Tm <8974> Tj 1 0 0 1 104.40 122.40 Tm <82F0> Tj 1 0 0 1 114.00 122.16 Tm <9770> Tj 1 0 0 1 124.32 123.36 Tm <82A2> Tj 1 0 0 1 133.92 122.88 Tm <82C4> Tj 1 0 0 1 143.52 122.40 Tm <905A> Tj 1 0 0 1 153.36 122.40 Tm <8F81> Tj 1 0 0 1 164.16 122.40 Tm <8CC5> Tj 1 0 0 1 174.24 122.40 Tm <92E8> Tj 1 0 0 1 185.76 123.12 Tm <82B5> Tj 1 0 0 1 194.64 123.36 Tm <82BD> Tj 1 0 0 1 204.24 122.40 Tm <8CE3> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 212.64 122.40 Tm <2C9085> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 231.60 122.64 Tm <90F4> Tj 0.00 Tc /F1 2.0 Tf 1 0 0 1 240.48 122.40 Tm <2C> Tj /F1 7.5 Tf 1 0 0 1 44.16 108.96 Tm <6D657468616E3031815D> Tj /F1 8.0 Tf 1 0 0 1 82.80 109.20 Tm <6D657468796C63656C6C6F736F6C766582F0> Tj 7.68 Tc 1 0 0 1 160.56 108.96 Tm <9770> Tj 1 0 0 1 169.92 110.16 Tm <82A2> Tj 1 0 0 1 178.56 109.68 Tm <82C4> Tj 1 0 0 1 186.72 108.96 Tm <9245> Tj 1 0 0 1 195.60 109.20 Tm <9085> Tj 0.00 Tc /F1 8.5 Tf 1 0 0 1 203.76 108.72 Tm <2C706F6C796573746572> Tj /F1 10.5 Tf 1 0 0 1 44.16 95.52 Tm <77617882C9> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 71.52 95.04 Tm <95EF> Tj 1 0 0 1 79.68 95.52 Tm <9684> Tj 1 0 0 1 90.00 95.76 Tm <82B5> Tj 1 0 0 1 97.68 95.76 Tm <82BD> Tj 0.00 Tc 1 0 0 1 106.08 95.04 Tm <2E3883CA> Tj /F1 10.5 Tf 1 0 0 1 124.08 96.00 Tm <6D82CC> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 141.84 95.52 Tm <9167> Tj 1 0 0 1 150.24 95.28 Tm <9044> Tj 1 0 0 1 159.12 95.52 Tm <90D8> Tj 1 0 0 1 168.24 95.76 Tm <95D0> Tj 1 0 0 1 177.12 96.00 Tm <82F0> Tj 1 0 0 1 185.28 95.52 Tm <8DEC> Tj 1 0 0 1 193.68 95.76 Tm <90AC> Tj 1 0 0 1 203.04 96.48 Tm <82B5> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 210.24 95.52 Tm <2C526F68486368> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 45.12 82.32 Tm <82CC> Tj 1 0 0 1 53.04 81.60 Tm <95FB> Tj 1 0 0 1 61.68 81.60 Tm <9640> Tj 0.00 Tc /F1 6.0 Tf 1 0 0 1 69.60 85.20 Tm <382982C5> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 84.96 83.52 Tm <8352> Tj 1 0 0 1 94.08 83.52 Tm <838D> Tj 1 0 0 1 102.24 82.32 Tm <8343> Tj 1 0 0 1 113.04 82.56 Tm <8368> Tj 1 0 0 1 118.80 81.84 Tm <9353> Tj 1 0 0 1 127.44 81.84 Tm <90F5> Tj 1 0 0 1 136.08 82.08 Tm <9046> Tj 1 0 0 1 145.92 82.56 Tm <82B5> Tj 1 0 0 1 153.60 82.56 Tm <82BD> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 162.00 81.84 Tm <2E8FE3> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 179.52 82.08 Tm <8B4C> Tj 1 0 0 1 188.88 83.04 Tm <82CC> Tj 1 0 0 1 196.80 82.08 Tm <8A65> Tj 1 0 0 1 205.20 82.08 Tm <8EC0> Tj 1 0 0 1 213.60 82.08 Tm <8CB1> Tj 1 0 0 1 222.48 82.08 Tm <8FF0> Tj 1 0 0 1 231.36 82.32 Tm <8C8F> Tj 1 0 0 1 240.72 82.32 Tm <89BA> Tj 1 0 0 1 45.12 68.88 Tm <82CC> Tj 1 0 0 1 53.04 68.16 Tm <96D4> Tj 1 0 0 1 61.20 68.16 Tm <968C> Tj 1 0 0 1 69.84 68.40 Tm <9046> Tj 1 0 0 1 78.00 68.16 Tm <9166> Tj 1 0 0 1 86.40 68.64 Tm <8FE3> Tj 1 0 0 1 95.28 68.16 Tm <94E7> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 104.16 67.92 Tm <2C8E8B> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 118.80 68.40 Tm <8DD7> Tj 1 0 0 1 127.20 68.40 Tm <9645> Tj 1 0 0 1 135.60 68.40 Tm <8A4F> Tj 1 0 0 1 144.00 68.64 Tm <90DF> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 152.64 68.40 Tm <2C82A8> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 168.96 69.36 Tm <82E6> Tj 1 0 0 1 176.88 69.36 Tm <82D1> Tj 1 0 0 1 185.28 68.64 Tm <93E0> Tj 1 0 0 1 193.20 68.64 Tm <90DF> Tj 1 0 0 1 201.60 68.88 Tm <9594> Tj 1 0 0 1 210.24 69.84 Tm <82CC> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 220.32 69.60 Tm <49504D82CC> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 389.04 672.72 Tm <93FA> Tj 1 0 0 1 395.76 672.48 Tm <8AE1> Tj 1 0 0 1 403.44 672.48 Tm <89EF> Tj 1 0 0 1 411.12 672.48 Tm <8E8F> Tj /F1 8.5 Tf 1 0 0 1 419.04 672.48 Tm <2039358AAA> Tj /F1 10.5 Tf 1 0 0 1 443.04 672.72 Tm <20358D86> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 269.04 648.96 Tm <90F5> Tj 1 0 0 1 277.68 649.44 Tm <9046> Tj 1 0 0 1 285.84 649.44 Tm <9594> Tj 1 0 0 1 294.24 649.44 Tm <88CA> Tj 1 0 0 1 303.84 650.16 Tm <82CC> Tj 1 0 0 1 312.24 649.20 Tm <95AA> Tj 1 0 0 1 320.40 649.44 Tm <957A> Tj 1 0 0 1 329.52 650.16 Tm <82C9> Tj 1 0 0 1 337.44 650.88 Tm <82C2> Tj 1 0 0 1 346.32 650.64 Tm <82A2> Tj 1 0 0 1 354.48 650.40 Tm <82C4> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 362.64 649.44 Tm <2C8CF5> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 379.68 649.68 Tm <8A77> Tj 1 0 0 1 388.32 649.68 Tm <8CB0> Tj 1 0 0 1 396.96 649.68 Tm <92A5> Tj 1 0 0 1 405.36 649.92 Tm <8BBE> Tj 1 0 0 1 414.48 650.64 Tm <82C5> Tj 1 0 0 1 422.40 649.92 Tm <8ACF> Tj 1 0 0 1 430.56 649.92 Tm <8E40> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 439.20 649.68 Tm <2C94E4> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 456.24 649.92 Tm <8A72> Tj 1 0 0 1 464.88 649.92 Tm <8C9F> Tj 1 0 0 1 269.04 635.52 Tm <93A2> Tj 1 0 0 1 278.88 636.48 Tm <82B5> Tj 1 0 0 1 286.08 636.48 Tm <82BD> Tj 1 0 0 1 294.72 635.76 Tm <8142> Tj 1 0 0 1 304.08 636.24 Tm <82C8> Tj 1 0 0 1 312.48 636.72 Tm <82A8> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 320.64 635.76 Tm <2C8CF5> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 337.44 636.00 Tm <8CB0> Tj 1 0 0 1 347.52 637.68 Tm <838C> Tj 1 0 0 1 354.72 638.16 Tm <8378> Tj 1 0 0 1 362.88 637.68 Tm <838B> Tj 1 0 0 1 371.52 636.96 Tm <82C5> Tj 1 0 0 1 380.40 637.20 Tm <82CD> Tj 1 0 0 1 388.32 636.00 Tm <90F5> Tj 1 0 0 1 397.44 636.48 Tm <9046> Tj 1 0 0 1 405.60 636.48 Tm <9594> Tj 1 0 0 1 414.72 637.20 Tm <82AA> Tj 1 0 0 1 422.40 636.48 Tm <8DD7> Tj 1 0 0 1 430.80 636.48 Tm <9645> Tj 1 0 0 1 438.96 636.48 Tm <955C> Tj 1 0 0 1 447.60 636.48 Tm <96CA> Tj 1 0 0 1 457.20 637.20 Tm <82C9> Tj 1 0 0 1 465.36 636.72 Tm <8CC0> Tj 1 0 0 1 269.04 622.08 Tm <8BC7> Tj 1 0 0 1 278.88 622.80 Tm <82B5> Tj 1 0 0 1 286.32 623.04 Tm <82C4> Tj 1 0 0 1 295.20 623.28 Tm <82A2> Tj 1 0 0 1 304.32 622.80 Tm <82E9> Tj 1 0 0 1 312.48 623.28 Tm <82CC> Tj 1 0 0 1 321.12 623.28 Tm <82A9> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 329.04 622.32 Tm <2C96D4> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 345.84 622.56 Tm <968C> Tj 1 0 0 1 354.24 622.80 Tm <89BA> Tj 1 0 0 1 362.40 622.56 Tm <8D6F> Tj 1 0 0 1 371.52 622.56 Tm <93E0> Tj 1 0 0 1 379.68 622.56 Tm <95A8> Tj 1 0 0 1 388.56 622.56 Tm <8EBF> Tj 1 0 0 1 398.16 623.28 Tm <82DC> Tj 1 0 0 1 406.08 623.52 Tm <82C5> Tj 1 0 0 1 414.48 622.56 Tm <95AA> Tj 1 0 0 1 422.40 622.80 Tm <957A> Tj 1 0 0 1 432.24 623.52 Tm <82B5> Tj 1 0 0 1 439.68 623.76 Tm <82C4> Tj 1 0 0 1 448.32 624.00 Tm <82A2> Tj 1 0 0 1 457.44 623.52 Tm <82E9> Tj 1 0 0 1 465.60 624.00 Tm <82CC> Tj 1 0 0 1 269.76 609.36 Tm <82A9> Tj 1 0 0 1 277.92 609.12 Tm <82F0> Tj 1 0 0 1 286.32 608.88 Tm <8BE6> Tj 1 0 0 1 294.48 608.88 Tm <95CA> Tj 1 0 0 1 303.60 608.88 Tm <82B7> Tj 1 0 0 1 313.20 609.36 Tm <82E9> Tj 1 0 0 1 321.12 609.84 Tm <82CC> Tj 1 0 0 1 329.76 609.84 Tm <82CD> Tj 1 0 0 1 337.92 609.12 Tm <8DA2> Tj 1 0 0 1 345.84 609.12 Tm <93EF> Tj 1 0 0 1 354.48 609.84 Tm <82C5> Tj 1 0 0 1 363.12 609.12 Tm <82A0> Tj 1 0 0 1 372.48 609.84 Tm <82C1> Tj 1 0 0 1 380.16 609.84 Tm <82BD> Tj 1 0 0 1 388.80 609.84 Tm <82BD> Tj 1 0 0 1 397.44 610.08 Tm <82DF> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 405.84 609.12 Tm <2C20> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 415.68 610.32 Tm <82B1> Tj 1 0 0 1 422.88 609.60 Tm <82EA> Tj 1 0 0 1 432.24 609.36 Tm <82E7> Tj 1 0 0 1 439.68 609.84 Tm <82F0> Tj 1 0 0 1 447.60 610.08 Tm <88EA> Tj 1 0 0 1 456.48 609.36 Tm <8A87> Tj 1 0 0 1 466.56 610.08 Tm <82B5> Tj 1 0 0 1 269.76 595.92 Tm <82C4> Tj 1 0 0 1 277.44 595.20 Tm <8ACF> Tj 1 0 0 1 286.08 595.20 Tm <8E40> Tj 1 0 0 1 294.72 594.96 Tm <8C8B> Tj 1 0 0 1 303.36 595.20 Tm <89CA> Tj 1 0 0 1 312.72 595.92 Tm <82C9> Tj 1 0 0 1 321.12 596.16 Tm <82CD> Tj 0.00 Tc /F1 10.0 Tf 1 0 0 1 331.20 596.16 Tm <49504D82C6> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 360.48 596.16 Tm <82B5> Tj 1 0 0 1 367.92 596.40 Tm <82C4> Tj 1 0 0 1 376.08 595.68 Tm <8B4C> Tj 1 0 0 1 384.48 595.68 Tm <8DDA> Tj 1 0 0 1 394.80 596.40 Tm <82B5> Tj 1 0 0 1 402.24 596.40 Tm <82BD> Tj 0.00 Tc /F1 2.5 Tf 1 0 0 1 410.64 595.68 Tm <2E> Tj 0.00 Tc /F1 11.5 Tf 1 0 0 1 338.16 575.28 Tm <49494920> Tj 5.76 Tc /F1 10.0 Tf 1 0 0 1 362.40 574.32 Tm <8C8B> Tj 0.00 Tc /F1 15.0 Tf 1 0 0 1 373.20 574.32 Tm <2020> Tj 5.76 Tc /F1 10.0 Tf 1 0 0 1 394.80 574.56 Tm <89CA> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 278.16 555.36 Tm <312E8389> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 301.44 555.36 Tm <8362> Tj 1 0 0 1 310.80 555.60 Tm <8367> Tj 1 0 0 1 317.04 555.36 Tm <82F0> Tj 1 0 0 1 324.96 554.88 Tm <88C3> Tj 1 0 0 1 333.60 555.12 Tm <8F87> Tj 1 0 0 1 341.76 555.12 Tm <899E> Tj 1 0 0 1 350.40 555.36 Tm <89BA> Tj 1 0 0 1 359.28 555.84 Tm <82C9> Tj 1 0 0 1 367.20 555.12 Tm <9FF3> Tj 1 0 0 1 375.84 555.12 Tm <97AC> Tj 1 0 0 1 384.72 555.12 Tm <8CC5> Tj 1 0 0 1 393.12 555.12 Tm <92E8> Tj 1 0 0 1 403.20 555.84 Tm <82B5> Tj 1 0 0 1 410.64 555.84 Tm <82BD> Tj 1 0 0 1 418.56 555.36 Tm <8FEA> Tj 1 0 0 1 426.96 555.36 Tm <8D87> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 435.36 555.12 Tm <2C8E8B> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 447.84 555.60 Tm <8DD7> Tj 1 0 0 1 456.72 555.60 Tm <9645> Tj 1 0 0 1 465.36 555.36 Tm <8A4F> Tj 1 0 0 1 269.76 540.96 Tm <90DF> Tj 1 0 0 1 278.16 541.20 Tm <9153> Tj 1 0 0 1 286.56 541.20 Tm <91CC> Tj 1 0 0 1 296.16 542.16 Tm <82A8> Tj 1 0 0 1 305.76 541.92 Tm <82E6> Tj 1 0 0 1 313.92 542.16 Tm <82D1> Tj 1 0 0 1 322.32 541.44 Tm <93E0> Tj 1 0 0 1 330.48 541.44 Tm <90DF> Tj 1 0 0 1 339.12 541.20 Tm <90E6> Tj 1 0 0 1 347.76 541.68 Tm <925B> Tj 1 0 0 1 356.16 541.68 Tm <9594> Tj 1 0 0 1 365.52 542.40 Tm <82CC> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 375.60 542.40 Tm <49504D82AA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 406.08 543.12 Tm <8372> Tj 1 0 0 1 414.00 543.84 Tm <837D> Tj 1 0 0 1 422.88 543.36 Tm <8393> Tj 1 0 0 1 430.32 541.92 Tm <90AB> Tj 1 0 0 1 439.44 542.64 Tm <82C9> Tj 1 0 0 1 447.36 541.92 Tm <90F5> Tj 1 0 0 1 456.48 542.16 Tm <9046> Tj 1 0 0 1 466.56 542.40 Tm <82B3> Tj 1 0 0 1 270.00 528.00 Tm <82EA> Tj 1 0 0 1 278.40 528.48 Tm <82BD> Tj 1 0 0 1 286.32 527.52 Tm <8142> Tj 1 0 0 1 294.24 528.48 Tm <82B5> Tj 1 0 0 1 301.92 528.72 Tm <82A9> Tj 1 0 0 1 311.52 528.48 Tm <82B5> Tj 0.00 Tc 1 0 0 1 318.72 527.76 Tm <2C93E0> Tj 5.76 Tc 1 0 0 1 333.12 528.00 Tm <90DF> Tj 1 0 0 1 341.76 528.00 Tm <8AEE> Tj 1 0 0 1 349.92 528.24 Tm <92EA> Tj 1 0 0 1 358.08 528.00 Tm <91A4> Tj 1 0 0 1 366.72 528.00 Tm <94BC> Tj 1 0 0 1 375.60 528.00 Tm <95AA> Tj 1 0 0 1 384.48 528.96 Tm <82CC> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 394.56 528.96 Tm <49504D82CD> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 423.60 529.20 Tm <82D9> Tj 1 0 0 1 432.72 528.96 Tm <82C6> Tj 1 0 0 1 440.16 529.20 Tm <82F1> Tj 1 0 0 1 449.52 528.96 Tm <82C7> Tj 1 0 0 1 456.96 528.48 Tm <90F5> Tj 1 0 0 1 465.60 528.72 Tm <9046> Tj 1 0 0 1 271.20 514.56 Tm <82B3> Tj 1 0 0 1 278.40 514.56 Tm <82EA> Tj 1 0 0 1 287.28 514.56 Tm <82C8> Tj 1 0 0 1 295.68 515.04 Tm <82A9> Tj 1 0 0 1 305.04 514.80 Tm <82C1> Tj 1 0 0 1 312.96 515.04 Tm <82BD> Tj 0.00 Tc /F1 7.0 Tf 1 0 0 1 325.92 514.56 Tm <28907D> Tj /F1 8.0 Tf 1 0 0 1 340.32 515.04 Tm <6C61206988C3> Tj 5.76 Tc 1 0 0 1 365.76 514.80 Tm <8F87> Tj 1 0 0 1 374.16 514.80 Tm <899E> Tj 1 0 0 1 383.04 514.80 Tm <8C5E> Tj 0.00 Tc /F1 5.5 Tf 1 0 0 1 391.68 514.80 Tm <292E> Tj /F1 9.0 Tf 1 0 0 1 278.16 501.36 Tm <322E8389> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 301.68 501.36 Tm <8362> Tj 1 0 0 1 311.04 501.60 Tm <8367> Tj 1 0 0 1 317.52 501.36 Tm <82F0> Tj 1 0 0 1 325.68 500.88 Tm <8EBA> Tj 1 0 0 1 334.56 501.12 Tm <93E0> Tj 1 0 0 1 342.96 500.88 Tm <8CF5> Tj 1 0 0 1 351.36 501.12 Tm <89BA> Tj 1 0 0 1 360.72 501.84 Tm <82C9> Tj 1 0 0 1 369.12 501.12 Tm <96BE> Tj 1 0 0 1 377.52 501.36 Tm <8F87> Tj 1 0 0 1 385.92 501.36 Tm <899E> Tj 1 0 0 1 396.48 501.84 Tm <82B3> Tj 1 0 0 1 403.92 502.08 Tm <82B9> Tj 1 0 0 1 413.04 502.08 Tm <82C4> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 423.60 502.08 Tm <3195AA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 438.72 501.36 Tm <8CE3> Tj 1 0 0 1 448.08 502.08 Tm <82C9> Tj 1 0 0 1 456.48 501.60 Tm <9FF3> Tj 1 0 0 1 465.60 501.60 Tm <97AC> Tj 1 0 0 1 270.00 487.20 Tm <8CC5> Tj 1 0 0 1 278.16 487.20 Tm <92E8> Tj 1 0 0 1 288.00 487.68 Tm <82B5> Tj 1 0 0 1 295.68 487.92 Tm <82BD> Tj 1 0 0 1 303.84 487.20 Tm <8FEA> Tj 1 0 0 1 312.72 487.44 Tm <8D87> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 321.12 486.96 Tm <2C8E8B> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 337.92 487.44 Tm <8DD7> Tj 1 0 0 1 346.32 487.44 Tm <9645> Tj 1 0 0 1 354.96 487.44 Tm <8A4F> Tj 1 0 0 1 363.12 487.68 Tm <90DF> Tj 1 0 0 1 371.76 487.44 Tm <90E6> Tj 1 0 0 1 380.16 487.68 Tm <925B> Tj 1 0 0 1 389.04 487.92 Tm <9594> Tj 1 0 0 1 398.16 488.40 Tm <82A8> Tj 1 0 0 1 407.28 488.40 Tm <82E6> Tj 1 0 0 1 415.44 488.40 Tm <82D1> Tj 1 0 0 1 423.12 487.92 Tm <8AEE> Tj 1 0 0 1 431.52 487.92 Tm <92EA> Tj 1 0 0 1 439.68 488.16 Tm <9594> Tj 0.00 Tc /F1 7.0 Tf 1 0 0 1 453.12 488.16 Tm <2893E0> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 465.84 488.16 Tm <90DF> Tj 1 0 0 1 269.76 473.52 Tm <90E6> Tj 1 0 0 1 278.16 473.76 Tm <925B> Tj 1 0 0 1 286.56 473.76 Tm <9594> Tj 1 0 0 1 295.92 474.24 Tm <82F0> Tj 1 0 0 1 304.08 473.76 Tm <8ADC> Tj 1 0 0 1 312.96 474.24 Tm <82DE> Tj 0.00 Tc /F1 7.0 Tf 1 0 0 1 321.12 474.00 Tm <2982CC> Tj /F1 10.5 Tf 1 0 0 1 336.00 474.72 Tm <49504D82AA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 363.84 474.24 Tm <91D1> Tj 1 0 0 1 372.48 474.24 Tm <8FF3> Tj 1 0 0 1 381.84 474.96 Tm <82C9> Tj 1 0 0 1 389.76 474.24 Tm <90F5> Tj 1 0 0 1 398.40 474.48 Tm <9046> Tj 1 0 0 1 408.00 474.72 Tm <82B3> Tj 1 0 0 1 415.44 474.72 Tm <82EA> Tj 1 0 0 1 424.08 474.96 Tm <82BD> Tj 1 0 0 1 432.00 474.24 Tm <8142> Tj 1 0 0 1 439.92 474.24 Tm <8A4F> Tj 1 0 0 1 448.32 474.48 Tm <90DF> Tj 1 0 0 1 457.44 474.72 Tm <9286> Tj 1 0 0 1 465.84 474.72 Tm <8AD4> Tj 1 0 0 1 270.00 460.32 Tm <9594> Tj 1 0 0 1 278.64 461.04 Tm <82CC> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 288.96 461.04 Tm <49504D82CC> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 317.52 460.32 Tm <90F5> Tj 1 0 0 1 326.16 460.56 Tm <9046> Tj 1 0 0 1 335.04 461.28 Tm <82CD> Tj 1 0 0 1 342.96 460.80 Tm <8EE3> Tj 1 0 0 1 351.60 461.28 Tm <82A9> Tj 1 0 0 1 360.96 461.28 Tm <82C1> Tj 1 0 0 1 368.40 461.28 Tm <82BD> Tj 1 0 0 1 376.56 460.56 Tm <8142> Tj 1 0 0 1 384.72 460.80 Tm <93E0> Tj 1 0 0 1 393.12 460.56 Tm <90DF> Tj 1 0 0 1 401.52 460.80 Tm <8AEE> Tj 1 0 0 1 410.16 460.80 Tm <92EA> Tj 1 0 0 1 418.56 461.04 Tm <9594> Tj 1 0 0 1 427.44 461.76 Tm <82CC> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 437.28 461.52 Tm <49504D82CD> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 466.32 461.76 Tm <82D9> Tj 1 0 0 1 271.44 447.12 Tm <82C6> Tj 1 0 0 1 278.88 447.36 Tm <82F1> Tj 1 0 0 1 288.24 447.12 Tm <82C7> Tj 1 0 0 1 295.68 446.64 Tm <90F5> Tj 1 0 0 1 304.32 446.88 Tm <9046> Tj 1 0 0 1 314.16 447.36 Tm <82B3> Tj 1 0 0 1 321.60 447.12 Tm <82EA> Tj 1 0 0 1 330.48 447.36 Tm <82C8> Tj 1 0 0 1 338.88 447.84 Tm <82A2> Tj 1 0 0 1 347.04 447.84 Tm <82A9> Tj 0.00 Tc /F1 10.0 Tf 1 0 0 1 354.96 446.88 Tm <2C82A0> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 372.96 447.60 Tm <82E9> Tj 1 0 0 1 381.12 448.08 Tm <82A2> Tj 1 0 0 1 389.76 448.08 Tm <82CD> Tj 1 0 0 1 397.92 447.36 Tm <9594> Tj 1 0 0 1 406.80 447.12 Tm <95AA> Tj 1 0 0 1 414.96 447.12 Tm <9349> Tj 1 0 0 1 424.08 448.08 Tm <82C9> Tj 1 0 0 1 432.72 448.32 Tm <82B2> Tj 1 0 0 1 441.84 447.60 Tm <82AD> Tj 1 0 0 1 448.56 448.08 Tm <82ED> Tj 1 0 0 1 457.20 447.60 Tm <82B8> Tj 1 0 0 1 466.32 448.32 Tm <82A9> Tj 1 0 0 1 270.72 433.92 Tm <82C9> Tj 1 0 0 1 278.40 432.96 Tm <90F5> Tj 1 0 0 1 287.28 433.44 Tm <9046> Tj 1 0 0 1 296.88 433.68 Tm <82B3> Tj 1 0 0 1 304.56 433.44 Tm <82EA> Tj 1 0 0 1 312.96 433.92 Tm <82BD> Tj 0.00 Tc /F1 7.0 Tf 1 0 0 1 322.08 433.44 Tm <28907D> Tj /F1 8.0 Tf 1 0 0 1 336.48 434.16 Tm <6C6220698F89> Tj 5.76 Tc 1 0 0 1 361.92 433.68 Tm <8AFA> Tj 1 0 0 1 370.80 433.44 Tm <96BE> Tj 1 0 0 1 378.96 433.68 Tm <8F87> Tj 1 0 0 1 387.60 433.68 Tm <899E> Tj 1 0 0 1 396.24 433.68 Tm <8C5E> Tj 0.00 Tc 1 0 0 1 404.88 433.68 Tm <292E8389> Tj 5.76 Tc 1 0 0 1 425.28 434.40 Tm <8362> Tj 1 0 0 1 434.40 434.64 Tm <8367> Tj 1 0 0 1 440.64 434.16 Tm <82F0> Tj 1 0 0 1 448.56 433.92 Tm <8EBA> Tj 1 0 0 1 457.68 433.92 Tm <93E0> Tj 1 0 0 1 466.08 433.92 Tm <8CF5> Tj 1 0 0 1 270.00 419.76 Tm <89BA> Tj 1 0 0 1 279.12 420.24 Tm <82C9> Tj 1 0 0 1 287.52 419.52 Tm <96BE> Tj 1 0 0 1 295.68 419.76 Tm <8F87> Tj 1 0 0 1 304.08 419.76 Tm <899E> Tj 1 0 0 1 314.40 420.24 Tm <82B3> Tj 1 0 0 1 321.60 420.72 Tm <82B9> Tj 1 0 0 1 330.24 420.48 Tm <82C4> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 340.32 420.72 Tm <352C31302C31352C333095AA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 406.56 420.24 Tm <8CE3> Tj 1 0 0 1 415.68 420.96 Tm <82C9> Tj 1 0 0 1 423.36 420.24 Tm <9FF3> Tj 1 0 0 1 431.76 420.24 Tm <97AC> Tj 1 0 0 1 440.40 420.48 Tm <8CC5> Tj 1 0 0 1 448.56 420.48 Tm <92E8> Tj 1 0 0 1 458.88 421.20 Tm <82B5> Tj 1 0 0 1 466.32 421.20 Tm <82BD> Tj 1 0 0 1 270.00 406.08 Tm <8FEA> Tj 1 0 0 1 278.40 406.32 Tm <8D87> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 287.04 405.84 Tm <2C8BA4> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 301.92 406.32 Tm <92CA> Tj 1 0 0 1 312.00 407.04 Tm <82B5> Tj 1 0 0 1 319.68 407.04 Tm <82C4> Tj 1 0 0 1 327.84 406.56 Tm <8E9F> Tj 1 0 0 1 336.48 407.28 Tm <82CC> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 346.56 407.28 Tm <49504D90F5> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 374.88 406.80 Tm <9046> Tj 1 0 0 1 383.76 407.52 Tm <82AA> Tj 1 0 0 1 391.92 406.80 Tm <8ACF> Tj 1 0 0 1 400.56 406.80 Tm <8E40> Tj 1 0 0 1 410.40 407.28 Tm <82B3> Tj 1 0 0 1 417.84 407.28 Tm <82EA> Tj 1 0 0 1 426.24 407.52 Tm <82BD> Tj 1 0 0 1 434.16 406.80 Tm <8142> Tj 1 0 0 1 439.92 406.80 Tm <8E8B> Tj 1 0 0 1 448.56 407.04 Tm <8DD7> Tj 1 0 0 1 457.44 407.04 Tm <9645> Tj 1 0 0 1 466.08 407.04 Tm <8A4F> Tj 1 0 0 1 270.24 392.64 Tm <90DF> Tj 1 0 0 1 278.64 392.64 Tm <90E6> Tj 1 0 0 1 287.28 392.88 Tm <925B> Tj 1 0 0 1 296.16 392.88 Tm <9594> Tj 1 0 0 1 305.52 393.84 Tm <82CC> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 315.84 393.60 Tm <49504D82AA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 343.92 393.12 Tm <91D1> Tj 1 0 0 1 352.56 393.12 Tm <8FF3> Tj 1 0 0 1 361.92 393.84 Tm <82C9> Tj 1 0 0 1 369.84 393.12 Tm <90F5> Tj 1 0 0 1 378.96 393.36 Tm <9046> Tj 1 0 0 1 388.80 393.60 Tm <82B3> Tj 1 0 0 1 396.48 393.60 Tm <82EA> Tj 1 0 0 1 406.08 393.84 Tm <82E9> Tj 1 0 0 1 415.20 393.84 Tm <82C6> Tj 1 0 0 1 424.08 393.84 Tm <82C6> Tj 1 0 0 1 432.48 393.60 Tm <82E0> Tj 1 0 0 1 440.64 394.08 Tm <82C9> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 448.32 393.36 Tm <2C8A4F> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 466.08 393.36 Tm <90DF> Tj 1 0 0 1 270.24 379.20 Tm <8AEE> Tj 1 0 0 1 278.64 379.20 Tm <92EA> Tj 1 0 0 1 287.52 379.44 Tm <9594> Tj 1 0 0 1 296.64 380.16 Tm <82A9> Tj 1 0 0 1 306.72 379.68 Tm <82E7> Tj 1 0 0 1 313.92 379.44 Tm <8E8B> Tj 1 0 0 1 322.56 379.68 Tm <8DD7> Tj 1 0 0 1 331.20 379.44 Tm <9645> Tj 1 0 0 1 340.32 379.44 Tm <93E0> Tj 1 0 0 1 348.48 379.44 Tm <90DF> Tj 1 0 0 1 357.12 379.68 Tm <9153> Tj 1 0 0 1 365.52 379.68 Tm <91CC> Tj 1 0 0 1 375.12 380.40 Tm <82C9> Tj 1 0 0 1 383.52 380.16 Tm <82ED> Tj 1 0 0 1 392.64 380.40 Tm <82BD> Tj 1 0 0 1 402.00 380.40 Tm <82C1> Tj 1 0 0 1 409.92 380.64 Tm <82C4> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 419.76 380.64 Tm <49504D82AA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 447.84 379.92 Tm <90F5> Tj 1 0 0 1 457.20 380.16 Tm <9046> Tj 1 0 0 1 467.52 380.40 Tm <82B3> Tj 1 0 0 1 270.72 366.00 Tm <82EA> Tj 1 0 0 1 279.12 366.24 Tm <82BD> Tj 1 0 0 1 287.04 365.52 Tm <8142> Tj 1 0 0 1 295.20 366.24 Tm <82DC> Tj 1 0 0 1 303.36 366.48 Tm <82BD> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 311.52 365.76 Tm <2C8A4F> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 326.88 365.76 Tm <90DF> Tj 1 0 0 1 335.76 366.00 Tm <9286> Tj 1 0 0 1 343.92 366.00 Tm <8AD4> Tj 1 0 0 1 352.08 366.24 Tm <9594> Tj 1 0 0 1 361.20 366.96 Tm <82CC> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 371.04 366.72 Tm <49504D82CC> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 399.84 366.00 Tm <90F5> Tj 1 0 0 1 408.72 366.48 Tm <9046> Tj 1 0 0 1 417.36 367.20 Tm <82CD> Tj 0.00 Tc /F1 8.5 Tf 1 0 0 1 425.28 366.00 Tm <2C96BE> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 440.40 366.48 Tm <8F87> Tj 1 0 0 1 448.56 366.48 Tm <899E> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 460.08 367.20 Tm <3195AA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 270.24 352.08 Tm <8CE3> Tj 1 0 0 1 280.32 352.80 Tm <82C6> Tj 1 0 0 1 287.76 352.32 Tm <93AF> Tj 1 0 0 1 295.68 352.32 Tm <976C> Tj 1 0 0 1 305.28 353.04 Tm <82C9> Tj 1 0 0 1 313.44 352.56 Tm <8EE3> Tj 1 0 0 1 322.08 353.28 Tm <82A9> Tj 1 0 0 1 331.44 353.04 Tm <82C1> Tj 1 0 0 1 338.88 353.28 Tm <82BD> Tj 0.00 Tc /F1 7.0 Tf 1 0 0 1 349.68 352.80 Tm <28907D> Tj /F1 7.5 Tf 1 0 0 1 364.08 353.28 Tm <6C63206996BE> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 389.76 352.80 Tm <8F87> Tj 1 0 0 1 398.16 352.80 Tm <899E> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 408.96 353.52 Tm <3595AA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 423.60 352.80 Tm <8CE3> Tj 0.00 Tc 1 0 0 1 435.36 354.24 Tm <3A8CE3> Tj 5.76 Tc 1 0 0 1 448.80 353.28 Tm <8AFA> Tj 1 0 0 1 457.92 353.04 Tm <96BE> Tj 1 0 0 1 466.32 353.28 Tm <8F87> Tj 1 0 0 1 270.24 338.64 Tm <899E> Tj 1 0 0 1 278.64 338.88 Tm <8C5E> Tj 0.00 Tc /F1 5.5 Tf 1 0 0 1 287.28 338.88 Tm <292E> Tj /F1 9.5 Tf 1 0 0 1 278.88 325.68 Tm <332E8389> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 302.40 325.68 Tm <8362> Tj 1 0 0 1 311.76 326.40 Tm <8367> Tj 1 0 0 1 318.24 326.40 Tm <82CC> Tj 1 0 0 1 326.64 325.68 Tm <8AE1> Tj 1 0 0 1 334.80 325.44 Tm <8B85> Tj 1 0 0 1 344.16 326.40 Tm <82C9> Tj 1 0 0 1 352.08 325.44 Tm <89DF> Tj 1 0 0 1 360.72 325.68 Tm <9378> Tj 1 0 0 1 369.84 326.64 Tm <82CC> Tj 1 0 0 1 378.24 325.68 Tm <8CF5> Tj 1 0 0 1 387.60 326.16 Tm <82F0> Tj 1 0 0 1 395.76 325.92 Tm <8FC6> Tj 1 0 0 1 404.64 325.92 Tm <8ECB> Tj 1 0 0 1 414.72 326.64 Tm <82B5> Tj 1 0 0 1 422.88 326.16 Tm <82C8> Tj 1 0 0 1 431.04 326.88 Tm <82AA> Tj 1 0 0 1 440.88 326.40 Tm <82E7> Tj 1 0 0 1 448.08 325.92 Tm <9FF3> Tj 1 0 0 1 457.20 326.16 Tm <97AC> Tj 1 0 0 1 466.56 326.16 Tm <8CC5> Tj 1 0 0 1 270.72 311.76 Tm <92E8> Tj 1 0 0 1 280.56 312.48 Tm <82B5> Tj 1 0 0 1 288.00 312.48 Tm <82BD> Tj 1 0 0 1 296.40 311.76 Tm <8FEA> Tj 1 0 0 1 305.76 312.00 Tm <8D87> Tj 0.00 Tc /F1 10.0 Tf 1 0 0 1 314.40 311.76 Tm <2C82D9> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 333.12 312.48 Tm <82C6> Tj 1 0 0 1 340.80 312.96 Tm <82F1> Tj 1 0 0 1 350.40 312.72 Tm <82C7> Tj 1 0 0 1 358.32 313.20 Tm <82CC> Tj 1 0 0 1 366.72 312.48 Tm <8AE1> Tj 1 0 0 1 375.36 312.24 Tm <8B85> Tj 1 0 0 1 384.72 312.48 Tm <9594> Tj 1 0 0 1 393.60 312.48 Tm <88CA> Tj 1 0 0 1 402.96 313.20 Tm <82C5> Tj 1 0 0 1 411.84 312.48 Tm <93E0> Tj 1 0 0 1 420.24 312.48 Tm <90DF> Tj 1 0 0 1 429.12 312.72 Tm <8EFC> Tj 1 0 0 1 438.00 312.72 Tm <88CD> Tj 1 0 0 1 446.88 313.44 Tm <82CC> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 456.96 313.44 Tm <49504D> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 271.20 299.28 Tm <82CD> Tj 1 0 0 1 279.12 298.56 Tm <8F57> Tj 1 0 0 1 287.52 298.08 Tm <90CF> Tj 1 0 0 1 297.60 299.04 Tm <82B5> Tj 1 0 0 1 305.04 299.04 Tm <82BD> Tj 1 0 0 1 314.40 299.04 Tm <82DC> Tj 1 0 0 1 322.80 299.04 Tm <82DC> Tj 1 0 0 1 330.72 299.52 Tm <82CC> Tj 1 0 0 1 338.88 298.80 Tm <8FF3> Tj 1 0 0 1 347.04 298.56 Tm <91D4> Tj 1 0 0 1 355.92 299.52 Tm <82C5> Tj 1 0 0 1 364.08 298.80 Tm <90F5> Tj 1 0 0 1 372.96 299.04 Tm <9046> Tj 1 0 0 1 382.56 299.28 Tm <82B3> Tj 1 0 0 1 390.24 299.28 Tm <82EA> Tj 1 0 0 1 399.60 299.52 Tm <82E9> Tj 1 0 0 1 408.72 299.52 Tm <82C6> Tj 1 0 0 1 417.12 299.52 Tm <82C6> Tj 1 0 0 1 425.28 299.28 Tm <82E0> Tj 1 0 0 1 432.96 299.76 Tm <82C9> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 440.64 298.80 Tm <2C88C3> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 457.68 299.28 Tm <8F87> Tj 1 0 0 1 466.32 299.28 Tm <899E> Tj 1 0 0 1 270.72 284.88 Tm <89BA> Tj 1 0 0 1 280.80 285.36 Tm <82C6> Tj 1 0 0 1 288.48 284.88 Tm <93AF> Tj 1 0 0 1 296.64 284.88 Tm <976C> Tj 1 0 0 1 306.24 285.84 Tm <82C9> Tj 1 0 0 1 314.40 284.88 Tm <8A4F> Tj 1 0 0 1 323.28 284.88 Tm <90DF> Tj 1 0 0 1 331.68 285.12 Tm <9153> Tj 1 0 0 1 340.32 285.12 Tm <91CC> Tj 1 0 0 1 349.44 285.84 Tm <82C9> Tj 1 0 0 1 357.60 285.84 Tm <82ED> Tj 1 0 0 1 366.48 285.84 Tm <82BD> Tj 1 0 0 1 375.84 285.84 Tm <82C1> Tj 1 0 0 1 383.76 286.08 Tm <82C4> Tj 1 0 0 1 393.84 286.80 Tm <8372> Tj 1 0 0 1 401.76 287.28 Tm <837D> Tj 1 0 0 1 410.88 287.04 Tm <8393> Tj 1 0 0 1 418.80 285.60 Tm <90AB> Tj 1 0 0 1 427.92 286.32 Tm <82C9> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 437.76 286.32 Tm <49504D82AA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 466.56 285.60 Tm <90F5> Tj 1 0 0 1 270.96 271.44 Tm <9046> Tj 1 0 0 1 280.32 271.92 Tm <82B3> Tj 1 0 0 1 288.00 271.68 Tm <82EA> Tj 1 0 0 1 296.64 272.16 Tm <82BD> Tj 1 0 0 1 305.04 271.44 Tm <8142> Tj 1 0 0 1 311.28 271.68 Tm <82B7> Tj 1 0 0 1 320.40 271.92 Tm <82C8> Tj 1 0 0 1 328.32 272.16 Tm <82ED> Tj 1 0 0 1 337.20 272.16 Tm <82BF> Tj 0.00 Tc /F1 8.5 Tf 1 0 0 1 345.12 271.44 Tm <2C8E8B> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 359.28 271.92 Tm <8DD7> Tj 1 0 0 1 367.68 271.92 Tm <9645> Tj 1 0 0 1 376.56 271.92 Tm <9177> Tj 1 0 0 1 384.96 271.92 Tm <9153> Tj 1 0 0 1 393.60 271.92 Tm <91CC> Tj 1 0 0 1 402.96 272.64 Tm <82C9> Tj 1 0 0 1 410.88 272.64 Tm <82ED> Tj 1 0 0 1 419.52 272.64 Tm <82BD> Tj 1 0 0 1 428.88 272.64 Tm <82C1> Tj 1 0 0 1 436.32 272.88 Tm <82C4> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 446.40 272.88 Tm <49504D82AA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 270.72 258.72 Tm <88EA> Tj 1 0 0 1 279.12 257.76 Tm <976C> Tj 1 0 0 1 288.24 258.48 Tm <82C9> Tj 1 0 0 1 296.64 258.00 Tm <8BAD> Tj 1 0 0 1 306.96 258.24 Tm <82AD> Tj 1 0 0 1 313.68 257.76 Tm <90F5> Tj 1 0 0 1 322.32 258.24 Tm <9046> Tj 1 0 0 1 332.16 258.72 Tm <82B3> Tj 1 0 0 1 339.60 258.48 Tm <82EA> Tj 1 0 0 1 348.24 258.96 Tm <82BD> Tj 0.00 Tc /F1 7.0 Tf 1 0 0 1 360.96 258.72 Tm <28907D> Tj /F1 8.0 Tf 1 0 0 1 375.84 258.96 Tm <6C64206989DF> Tj 5.76 Tc 1 0 0 1 402.24 258.24 Tm <9378> Tj 1 0 0 1 410.88 258.24 Tm <8CF5> Tj 1 0 0 1 419.52 258.48 Tm <8FC6> Tj 1 0 0 1 427.92 258.48 Tm <8ECB> Tj 1 0 0 1 436.56 258.72 Tm <8C5E> Tj 0.00 Tc /F1 3.5 Tf 1 0 0 1 444.96 258.72 Tm <298142> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 459.36 259.44 Tm <82B5> Tj 1 0 0 1 467.04 259.68 Tm <82A9> Tj 1 0 0 1 272.40 245.04 Tm <82B5> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 279.36 244.32 Tm <2C90D8> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 292.32 244.56 Tm <95D0> Tj 1 0 0 1 301.44 245.28 Tm <82C9> Tj 1 0 0 1 310.56 245.28 Tm <82E6> Tj 1 0 0 1 319.20 245.28 Tm <82C1> Tj 1 0 0 1 326.88 245.28 Tm <82C4> Tj 1 0 0 1 335.52 245.76 Tm <82CD> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 343.20 244.56 Tm <2C8AE1> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 355.68 244.80 Tm <8B85> Tj 1 0 0 1 364.32 244.80 Tm <90D4> Tj 1 0 0 1 372.96 244.80 Tm <93B9> Tj 1 0 0 1 381.60 245.04 Tm <9594> Tj 1 0 0 1 390.48 245.76 Tm <82CC> Tj 1 0 0 1 398.64 245.76 Tm <88EA> Tj 1 0 0 1 407.28 245.04 Tm <9594> Tj 1 0 0 1 416.16 245.76 Tm <82C5> Tj 1 0 0 1 424.56 245.04 Tm <96BE> Tj 1 0 0 1 432.72 245.28 Tm <8F87> Tj 1 0 0 1 440.88 245.28 Tm <899E> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 451.44 246.00 Tm <358160> Tj /F1 7.0 Tf 1 0 0 1 466.80 245.76 Tm <3330> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 271.20 230.88 Tm <95AA> Tj 1 0 0 1 280.80 231.36 Tm <82C6> Tj 1 0 0 1 288.24 230.88 Tm <93AF> Tj 1 0 0 1 296.40 231.12 Tm <976C> Tj 1 0 0 1 305.76 231.84 Tm <82CC> Tj 1 0 0 1 313.68 230.88 Tm <90F5> Tj 1 0 0 1 322.56 231.36 Tm <9046> Tj 1 0 0 1 330.72 231.12 Tm <919C> Tj 0.00 Tc /F1 7.0 Tf 1 0 0 1 343.92 231.36 Tm <288CE3> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 355.92 231.36 Tm <8AFA> Tj 1 0 0 1 364.80 231.36 Tm <96BE> Tj 1 0 0 1 372.96 231.36 Tm <8F87> Tj 1 0 0 1 381.36 231.36 Tm <899E> Tj 1 0 0 1 390.24 231.60 Tm <8C5E> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 398.88 231.60 Tm <2982AA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 415.68 231.60 Tm <8ACF> Tj 1 0 0 1 424.32 231.60 Tm <8E40> Tj 1 0 0 1 433.92 232.08 Tm <82B3> Tj 1 0 0 1 441.12 232.08 Tm <82EA> Tj 1 0 0 1 449.76 232.32 Tm <82BD> Tj 1 0 0 1 458.16 231.60 Tm <8142> Tj 0.00 Tc /F1 15.0 Tf 1 0 0 1 339.84 210.96 Tm <49568D6C> Tj 1 0 0 1 379.44 210.00 Tm <20> Tj 12.00 Tc /F1 10.0 Tf 1 0 0 1 395.76 210.24 Tm <88C2> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 279.84 190.32 Tm <8DA1> Tj 1 0 0 1 288.48 190.80 Tm <89F1> Tj 1 0 0 1 297.12 191.28 Tm <82CC> Tj 1 0 0 1 305.28 190.56 Tm <8EC0> Tj 1 0 0 1 313.68 190.56 Tm <8CB1> Tj 1 0 0 1 323.04 191.28 Tm <82C9> Tj 1 0 0 1 331.20 191.28 Tm <82A8> Tj 1 0 0 1 339.84 191.76 Tm <82A2> Tj 1 0 0 1 348.24 191.52 Tm <82C4> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 356.16 190.56 Tm <2C88C3> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 373.20 190.80 Tm <8FF3> Tj 1 0 0 1 381.60 190.80 Tm <91D4> Tj 1 0 0 1 390.96 191.76 Tm <82A9> Tj 1 0 0 1 400.32 191.28 Tm <82E7> Tj 1 0 0 1 408.00 191.04 Tm <96BE> Tj 1 0 0 1 416.16 191.04 Tm <8FF3> Tj 1 0 0 1 424.32 191.04 Tm <91D4> Tj 1 0 0 1 432.96 192.96 Tm <82D6> Tj 1 0 0 1 441.12 191.04 Tm <8CF5> Tj 1 0 0 1 449.28 191.28 Tm <8AC2> Tj 1 0 0 1 458.16 191.04 Tm <8BAB> Tj 1 0 0 1 467.28 192.24 Tm <82AA> Tj 1 0 0 1 271.20 176.88 Tm <95CF> Tj 1 0 0 1 279.60 176.88 Tm <89BB> Tj 1 0 0 1 288.48 177.12 Tm <82B7> Tj 1 0 0 1 298.32 177.60 Tm <82E9> Tj 1 0 0 1 306.72 177.84 Tm <82CC> Tj 1 0 0 1 315.60 177.84 Tm <82C9> Tj 1 0 0 1 323.52 177.12 Tm <94BA> Tj 1 0 0 1 333.12 177.84 Tm <82C1> Tj 1 0 0 1 340.80 178.08 Tm <82C4> Tj 1 0 0 1 349.44 178.08 Tm <82A8> Tj 1 0 0 1 359.04 178.56 Tm <82B1> Tj 1 0 0 1 367.20 177.84 Tm <82E9> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 376.80 178.08 Tm <49504D95AA> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 405.84 177.36 Tm <957A> Tj 1 0 0 1 415.20 178.56 Tm <82CC> Tj 1 0 0 1 423.60 177.60 Tm <95CF> Tj 1 0 0 1 432.00 177.60 Tm <89BB> Tj 1 0 0 1 441.36 178.08 Tm <82F0> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 449.28 177.60 Tm <2C8CF5> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 467.52 178.80 Tm <82CC> Tj 1 0 0 1 271.44 163.44 Tm <8BAD> Tj 1 0 0 1 280.80 163.92 Tm <82B3> Tj 1 0 0 1 289.68 163.92 Tm <82C6> Tj 1 0 0 1 296.88 163.20 Tm <8CF5> Tj 1 0 0 1 305.52 163.44 Tm <8FC6> Tj 1 0 0 1 314.16 163.68 Tm <8ECB> Tj 1 0 0 1 322.80 163.68 Tm <8E9E> Tj 1 0 0 1 331.20 163.68 Tm <8AD4> Tj 1 0 0 1 339.84 164.16 Tm <82F0> Tj 1 0 0 1 348.24 165.84 Tm <8370> Tj 1 0 0 1 357.60 164.64 Tm <8389> Tj 1 0 0 1 365.76 165.36 Tm <8381> Tj 1 0 0 1 374.40 165.36 Tm <815B> Tj 1 0 0 1 383.04 164.88 Tm <835E> Tj 1 0 0 1 391.68 165.36 Tm <815B> Tj 1 0 0 1 400.56 164.40 Tm <82C6> Tj 1 0 0 1 409.20 164.64 Tm <82B5> Tj 1 0 0 1 416.64 164.88 Tm <82C4> Tj 1 0 0 1 424.32 164.16 Tm <92B2> Tj 1 0 0 1 432.96 165.84 Tm <82D7> Tj 1 0 0 1 441.60 164.88 Tm <82BD> Tj 1 0 0 1 449.76 164.16 Tm <8142> Tj 1 0 0 1 458.40 164.16 Tm <90E6> Tj 1 0 0 1 467.52 165.12 Tm <82CC> Tj 1 0 0 1 271.20 149.76 Tm <95F1> Tj 1 0 0 1 279.60 149.76 Tm <8D90> Tj 0.00 Tc /F1 4.0 Tf 1 0 0 1 288.00 153.84 Tm <32298160> Tj /F1 6.0 Tf 1 0 0 1 297.36 153.84 Tm <342982F0> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 311.28 150.24 Tm <8A6D> Tj 1 0 0 1 319.92 150.24 Tm <9446> Tj 1 0 0 1 328.32 150.24 Tm <82B7> Tj 1 0 0 1 337.68 150.72 Tm <82E9> Tj 1 0 0 1 346.56 150.72 Tm <82C6> Tj 1 0 0 1 355.20 150.96 Tm <82C6> Tj 1 0 0 1 363.12 150.48 Tm <82E0> Tj 1 0 0 1 371.04 151.20 Tm <82C9> Tj 0.00 Tc /F1 11.5 Tf 1 0 0 1 379.20 150.24 Tm <2C49504D82CC> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 416.16 150.24 Tm <8CF5> Tj 1 0 0 1 424.32 150.72 Tm <899E> Tj 1 0 0 1 432.72 150.72 Tm <939A> Tj 1 0 0 1 441.60 150.96 Tm <82F0> Tj 1 0 0 1 450.72 151.44 Tm <82E6> Tj 1 0 0 1 460.32 151.20 Tm <82E8> Tj 1 0 0 1 467.04 150.72 Tm <8FDA> Tj 1 0 0 1 271.44 136.56 Tm <8DD7> Tj 1 0 0 1 280.32 137.04 Tm <82C9> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 288.24 136.32 Tm <2C93AE> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 305.76 136.80 Tm <9349> Tj 1 0 0 1 314.88 137.28 Tm <82C9> Tj 1 0 0 1 322.56 136.80 Tm <9463> Tj 1 0 0 1 330.96 137.04 Tm <88AC> Tj 1 0 0 1 339.60 136.80 Tm <82B7> Tj 1 0 0 1 348.96 137.52 Tm <82E9> Tj 1 0 0 1 357.84 138.00 Tm <82B1> Tj 1 0 0 1 366.24 137.52 Tm <82C6> Tj 1 0 0 1 373.68 137.76 Tm <82AA> Tj 1 0 0 1 382.32 137.76 Tm <82C5> Tj 1 0 0 1 391.92 137.04 Tm <82AB> Tj 1 0 0 1 399.60 137.76 Tm <82BD> Tj 1 0 0 1 408.00 137.04 Tm <8142> Tj 1 0 0 1 416.40 137.28 Tm <82B7> Tj 1 0 0 1 425.52 137.52 Tm <82C8> Tj 1 0 0 1 433.20 137.76 Tm <82ED> Tj 1 0 0 1 442.08 137.76 Tm <82BF> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 450.00 137.04 Tm <2C88C3> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 467.28 137.52 Tm <8F87> Tj 1 0 0 1 271.20 122.88 Tm <899E> Tj 1 0 0 1 279.84 123.12 Tm <89BA> Tj 1 0 0 1 288.72 123.60 Tm <82C5> Tj 1 0 0 1 297.60 123.84 Tm <82CD> Tj 1 0 0 1 305.52 123.12 Tm <8E8B> Tj 1 0 0 1 314.16 123.36 Tm <8DD7> Tj 1 0 0 1 322.80 123.12 Tm <9645> Tj 1 0 0 1 331.20 123.12 Tm <8A4F> Tj 1 0 0 1 339.84 123.36 Tm <90DF> Tj 1 0 0 1 348.24 123.36 Tm <8EFC> Tj 1 0 0 1 356.88 123.36 Tm <88CD> Tj 1 0 0 1 364.80 123.36 Tm <9153> Tj 1 0 0 1 373.44 123.36 Tm <91CC> Tj 1 0 0 1 382.08 123.36 Tm <8B79> Tj 1 0 0 1 391.44 124.32 Tm <82D1> Tj 1 0 0 1 399.84 123.60 Tm <93E0> Tj 1 0 0 1 408.00 123.60 Tm <90DF> Tj 1 0 0 1 416.40 123.60 Tm <90E6> Tj 1 0 0 1 424.56 123.84 Tm <925B> Tj 1 0 0 1 432.96 123.84 Tm <9594> Tj 1 0 0 1 442.08 124.56 Tm <82C9> Tj 1 0 0 1 451.68 125.28 Tm <8372> Tj 1 0 0 1 459.36 125.76 Tm <837D> Tj 1 0 0 1 468.48 125.28 Tm <8393> Tj 1 0 0 1 271.68 109.44 Tm <90AB> Tj 1 0 0 1 280.56 110.16 Tm <82C9> Tj 1 0 0 1 288.72 109.20 Tm <95AA> Tj 1 0 0 1 297.12 109.44 Tm <957A> Tj 1 0 0 1 307.20 110.16 Tm <82B5> Tj 1 0 0 1 314.88 110.40 Tm <82C4> Tj 1 0 0 1 323.52 110.64 Tm <82A2> Tj 1 0 0 1 331.68 110.40 Tm <82BD> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 341.76 110.64 Tm <49504D2888C3> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 374.88 110.16 Tm <8F87> Tj 1 0 0 1 383.52 109.92 Tm <899E> Tj 1 0 0 1 392.16 110.16 Tm <8C5E> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 400.80 110.16 Tm <2982AA> Tj 1 0 0 1 416.64 109.92 Tm <2C82DC> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 433.20 110.16 Tm <82B8> Tj 1 0 0 1 441.60 110.16 Tm <8EBA> Tj 1 0 0 1 450.48 110.40 Tm <93E0> Tj 1 0 0 1 458.88 110.16 Tm <8CF5> Tj 1 0 0 1 468.24 111.12 Tm <82C9> Tj 1 0 0 1 271.44 96.00 Tm <899E> Tj 1 0 0 1 280.08 96.00 Tm <939A> Tj 1 0 0 1 289.92 96.72 Tm <82B5> Tj 1 0 0 1 297.60 96.72 Tm <82C4> Tj 1 0 0 1 306.00 96.00 Tm <8A4F> Tj 1 0 0 1 314.40 96.00 Tm <90DF> Tj 1 0 0 1 323.04 96.00 Tm <90E6> Tj 1 0 0 1 331.20 96.48 Tm <925B> Tj 1 0 0 1 339.84 96.48 Tm <9594> Tj 1 0 0 1 348.72 97.20 Tm <82A8> Tj 1 0 0 1 357.84 97.20 Tm <82E6> Tj 1 0 0 1 365.76 97.20 Tm <82D1> Tj 1 0 0 1 373.68 96.48 Tm <8AEE> Tj 1 0 0 1 382.32 96.48 Tm <92EA> Tj 1 0 0 1 390.72 96.72 Tm <9594> Tj 0.00 Tc /F1 7.0 Tf 1 0 0 1 400.08 96.72 Tm <2893E0> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 412.32 96.72 Tm <90DF> Tj 1 0 0 1 420.72 96.72 Tm <90E6> Tj 1 0 0 1 429.12 96.96 Tm <925B> Tj 1 0 0 1 437.28 96.96 Tm <9594> Tj 1 0 0 1 446.16 97.20 Tm <82F0> Tj 1 0 0 1 454.56 96.96 Tm <8ADC> Tj 1 0 0 1 463.44 97.20 Tm <82DE> Tj 0.00 Tc /F1 5.5 Tf 1 0 0 1 471.84 96.96 Tm <29> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 271.92 84.24 Tm <82D6> Tj 1 0 0 1 280.32 82.32 Tm <95AA> Tj 1 0 0 1 288.48 82.56 Tm <957A> Tj 1 0 0 1 297.12 82.56 Tm <945A> Tj 1 0 0 1 306.00 82.56 Tm <8F6B> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 318.00 82.80 Tm <2895AA> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 330.00 82.80 Tm <97A3> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 338.40 82.80 Tm <2982B7> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 354.96 83.52 Tm <82E9> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 365.76 83.04 Tm <288F89> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 377.76 83.04 Tm <8AFA> Tj 1 0 0 1 387.12 83.04 Tm <96BE> Tj 1 0 0 1 395.28 83.28 Tm <8F87> Tj 1 0 0 1 403.92 83.28 Tm <899E> Tj 1 0 0 1 412.32 83.28 Tm <8C5E> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 420.96 83.28 Tm <292E8CF5> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 441.84 83.28 Tm <8FC6> Tj 1 0 0 1 450.24 83.52 Tm <8ECB> Tj 1 0 0 1 459.36 84.24 Tm <82CC> Tj 1 0 0 1 467.76 83.28 Tm <8E9E> Tj 1 0 0 1 271.92 69.12 Tm <8AD4> Tj 1 0 0 1 280.56 69.84 Tm <82AA> Tj 1 0 0 1 289.20 70.08 Tm <82CC> Tj 1 0 0 1 297.84 70.08 Tm <82D1> Tj 1 0 0 1 307.20 69.84 Tm <82E9> Tj 1 0 0 1 316.08 69.84 Tm <82C6> Tj 0.00 Tc /F1 8.5 Tf 1 0 0 1 323.28 69.12 Tm <2C8E9F> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 338.16 70.32 Tm <82CC> Tj 1 0 0 1 345.84 69.60 Tm <9269> Tj 1 0 0 1 354.72 69.60 Tm <8A4B> Tj 1 0 0 1 364.32 70.32 Tm <82C6> Tj 1 0 0 1 372.72 70.32 Tm <82B5> Tj 1 0 0 1 380.40 70.56 Tm <82C4> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 388.80 69.60 Tm <2C8A4F> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 403.44 69.60 Tm <90DF> Tj 1 0 0 1 412.08 70.08 Tm <8EFC> Tj 1 0 0 1 420.96 70.08 Tm <88CD> Tj 1 0 0 1 429.12 70.80 Tm <82CC> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 439.20 70.80 Tm <49504D82CD> Tj 7.68 Tc /F1 8.0 Tf 1 0 0 1 467.52 70.32 Tm <97BC> Tj ET endstream endobj 5 0 obj <>stream I緒 言 光受容体間基質GnterphOtOreceptor matrix,IPM)は,網膜色素上皮と視細胞外節,内節周囲の網膜下腔を満たし,さまざまな重要な機能を有している1)。最近筆者らは,明暗の光環境の変化に依存してラットIPM成分の局在部位が変化することを発見した2)〜4)。すなわち,暗順応下では,視細胞外節全体および内節先端部にビマン性にIPMが分布するのに対し,明順応下(室内蛍光灯下)では,視細胞外節先端部と外節基底部から内節全体にわたってIPMが分布する2)〜4)。ところで,網膜の病態とIPMとの関連については,遺伝性視細胞変性ラットの視細胞変性過程にIPMの異常が関与しているとの報告がある。)。また,過度の光,あるいは通常の蛍光灯でも連続して照射すると, ラットあるいはマウスの視細胞が変性することが知られている0)7).この場合,過度の光照射によってIPMの光応答の異常が起こり,視細胞変性が引き起こされている可能性がある.そこで本研究においては,過度の光照射を含め,先の報告2)-4)よりもさらに細かく光の条件を変化させた場合のIPM分布の様式について比較検討した。 II 実験方法白色成熟ラット(RCS‐rdy■:8〜10週齢)を,明{7AM照明on:Cage部照度は20 foot‐candle(ft‐c)}:暗(7PM照明o“)=12:12時間周期下に飼育した。ラットを暗順応(絶対暗室:夜どうし12時間:7AMに以下の実験を開始)させた後, 7群(各群3匹)に分け,以下の光条件のもとに炭酸ガスを吸引させることによって安楽死させた.1)暗順応を継続,2)明順応(Cage部照度は50ft‐c:7AM照明on)1, 5,10,15,30分後,3)過度の光(照度は500ft‐c)照射10分.先に報告した方法2)〜4)に従って,固定液に2.5%glutar―aldehyde, 2%parafOrmaldehyde(0.lM phosphatebu“er,pH 7.3,37℃)を使用して直ちにラットを灌流固定した。灌流固定の間,ずっとそれぞれ安楽死前と同じ光条件を維持(頭部を黒色テープで被覆あるいは光を照射)した。眼寓内容除去を行い,眼球を一晩さらに同固定液を用いて浸潤固定した後,水洗,methan01‐methylcellosolveを用いて脱水,polyesterwaxに包埋した.8μmの組織切片を作成し,RohHchの方法8)でコロイド鉄染色した.上記の各実験条件下の網膜色素上皮,視細胞外節,および内節部のIPMの 日眼会誌 95巻 5号 染色部位の分布について,光学顕徴鏡で観察,比較検討した。なお,光顕レベルでは染色部が細胞表面に限局しているのか,網膜下腔内物質まで分布しているのかを区別するのは困難であったため, これらを一括して観察結果にはIPMとして記載した. III 結 果 1.ラットを暗順応下に灌流固定した場合,視細胞外節全体および内節先端部のIPMがビマン性に染色された。しかし,内節基底側半分のIPMはほとんど染色されなかった(図la i暗順応型).2.ラットを室内光下に明順応させて1分後に灌流固定した場合,視細胞外節先端部および基底部(内節先端部を含む)のIPMが帯状に染色された。外節中間部のIPMの染色は弱かった。内節基底部のIPMはほとんど染色されないか,あるいは部分的にごくわずかに染色された(図lb i初期明順応型).ラットを室内光下に明順応させて5,10,15,30分後に灌流固定した場合,共通して次のIPM染色が観察された。視細胞外節先端部のIPMが帯状に染色されるとともに,外節基底部から視細胞内節全体にわたってIPMが染色された。また,外節中間部のIPMの染色は,明順応1分後と同様に弱かった(図lc i明順応5分後:後期明順応型).3.ラットの眼球に過度の光を照射しながら灌流固定した場合,ほとんどの眼球部位で内節周囲のIPMは集積したままの状態で染色されるとともに,暗順応下と同様に外節全体にわたってビマン性にIPMが染色された。すなわち,視細胞層全体にわたってIPMが一様に強く染色された(図ld i過度光照射型)。しかし,切片によっては,眼球赤道部の一部で明順応5〜30分と同様の染色像(後期明順応型)が観察された。IV考 按 今回の実験において,暗状態から明状態へ光環境が変化するのに伴っておこるIPM分布の変化を,光の強さと光照射時間をパラメーターとして調べた。先の報告2)〜4)を確認するとともに,IPMの光応答をより詳細に,動的に把握することができた。すなわち,暗順応下では視細胞外節周囲全体及び内節先端部にビマン性に分布していたIPM(暗順応型)が,まず室内光に応答して外節先端部および基底部(内節先端部を含む)へ分布濃縮(分離)する(初期明順応型).光照射の時間がのびると,次の段階として,外節周囲のIPMは両 endstream endobj 6 0 obj <>stream リ JFIF ロ C #*%,+)%((.4B8.1?2((:N:?DGJKJ-7QWQHVBIJGロ C ""G0(0GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGタ i ト ト オ } !1AQa"q2¢。#BアチRム$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyzヤ炎駐舶沫劒「」、・ヲァィゥェイウエオカキクケコツテトナニヌネノハメモヤユヨラリルレ矮聿褂鉅鳰ト ト オ w !1AQaq"2B贈アチ #3Rbrム $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyzcу炎駐舶沫劒「」、・ヲァィゥェイウエオカキクケコツテトナニヌネノハメモヤユヨラリルレ粤蒟跚韜レ ? 筒ネ゙ゥ5ナ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@J :ミ@ P@ P@ P@ P@ P@ P@ P@ P@G4 zPァ x楸 灣@ P@ P@ P@ P@ P@ ヲ@ P h n P@ 諤2」 証゙ヲJ5ゥ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ P@ )BP0 ( ( ( 4 P@ P@顱 P@ P@ P@ P@ h P@ P@ P@ P@ P@ P@ 「 @ツ ( ( 1@ L P1@ P@ P@ P@ P@ P@ P@ P ( @ ^エ エ~テ」Zb ( Z 1@ % (M Z% ( S@│bミ!(P@ Pミ ナp≦ クAメ ( ( Z% (E@Z J)BP0ナ≦ P≦ P@@│a@ エ:ミP0 -ミ1(P@ P@ P@ P@ P@ -≦ )BP0J P@@≦ P@ P@ P@ P@ )((( 3@ P@@│a@ P@ P@ P@ E 6}(h&?麝婆R(( P 4 1@@4 P P h 4 J(@h(P@ (@h % \P 顱@│4 P (b≦ %P ナ P@( ナ h ナ P 1@( 4 1@ナpナP 1@クPP0@ WP; b ÷Z瓠 &(bP ナ % - J(A@ ( 1@ P h(エa (b≦ % S@│a@ P% ( ( 1@( 4 エ!、 1@ @ミ!(Pミ 4 \P PP0 (E≦ P@zミ スhh*?)イQォHa@ナ顱ミ (hP@ ( a@ ÷ Pミ!( C@ナ @a LP;Bミ@ P@ ( ♂pナ -ミ1hNエ ス(簟 b タミZ P@ 、@qh P@ クエ( クb⌒ tLZ ( A@ (3@XZ (:ミ0 □`(エ °@ミ ( 4 b⌒Z Sー ( vエXAH C@ミP @タミb@ ( 4 BP1(P@摺4Z Pf°@ナクbZ Lミ1h°@ %P!(「@4 ミ1(P@zミ スhh&?(%ヤQ@(hP@ ( ( ≦ P@1( ! 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