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0 1 140.64 363.36 Tm <93E0> Tj 1 0 0 1 149.04 363.12 Tm <8FE1> Tj 1 0 0 1 157.44 362.88 Tm <94AD> Tj 1 0 0 1 165.84 363.60 Tm <90B6> Tj 1 0 0 1 174.48 363.36 Tm <9668> Tj 1 0 0 1 183.12 363.36 Tm <8CE4> Tj 1 0 0 1 192.00 363.36 Tm <8D79> Tj 1 0 0 1 201.12 363.36 Tm <9166> Tj 1 0 0 1 211.44 364.08 Tm <82C6> Tj 1 0 0 1 219.84 364.08 Tm <82B5> Tj 1 0 0 1 227.52 364.32 Tm <82C4> Tj 1 0 0 1 235.68 363.36 Tm <928D> Tj 1 0 0 1 40.80 349.68 Tm <96DA> Tj 1 0 0 1 48.24 349.68 Tm <82F0> Tj 1 0 0 1 56.88 349.44 Tm <9781> Tj 1 0 0 1 66.24 350.16 Tm <82D1> Tj 1 0 0 1 74.88 350.16 Tm <82C4> Tj 1 0 0 1 83.28 350.40 Tm <82A2> Tj 1 0 0 1 92.16 350.16 Tm <82E9> Tj 1 0 0 1 99.12 349.68 Tm <8D79> Tj 1 0 0 1 107.52 349.44 Tm <9166> Tj 1 0 0 1 116.64 350.40 Tm <82C5> Tj 1 0 0 1 126.48 349.92 Tm <82E0> Tj 1 0 0 1 134.40 349.92 Tm <82A0> Tj 1 0 0 1 143.52 350.40 Tm <82E9> Tj 1 0 0 1 150.72 349.68 Tm <8142> Tj 1 0 0 1 160.32 350.88 Tm <82B1> Tj 1 0 0 1 167.52 350.64 Tm <82CC> Tj 1 0 0 1 175.68 350.64 Tm <82BD> Tj 1 0 0 1 184.56 350.64 Tm <82DF> Tj 1 0 0 1 193.44 349.92 Tm <91BD> Tj 1 0 0 1 202.08 349.92 Tm <9094> Tj 1 0 0 1 211.20 350.88 Tm <82CC> Tj 1 0 0 1 218.88 349.92 Tm <8CA4> Tj 1 0 0 1 227.52 350.16 Tm <8B86> Tj 1 0 0 1 235.44 350.16 Tm <95F1> Tj 1 0 0 1 39.12 335.76 Tm <8D90> Tj 1 0 0 1 48.24 336.72 Tm <82AA> Tj 1 0 0 1 57.60 336.24 Tm <82C8> Tj 1 0 0 1 66.96 336.48 Tm <82B3> Tj 1 0 0 1 74.64 336.24 Tm <82EA> Tj 1 0 0 1 83.28 336.72 Tm <82C4> Tj 1 0 0 1 92.16 336.00 Tm <82AB> Tj 1 0 0 1 99.60 336.72 Tm <82C4> Tj 1 0 0 1 108.24 337.20 Tm <82A2> Tj 1 0 0 1 117.36 336.72 Tm <82E9> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 125.28 340.08 Tm <3122292E> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 49.44 322.80 Tm <82C6> Tj 1 0 0 1 58.32 323.52 Tm <82B1> Tj 1 0 0 1 66.48 322.80 Tm <82EB> Tj 1 0 0 1 74.64 323.28 Tm <82C5> Tj 0.00 Tc /F1 10.0 Tf 1 0 0 1 82.80 322.08 Tm <2C9856> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 99.36 322.80 Tm <906C> Tj 1 0 0 1 107.76 322.80 Tm <90AB> Tj 1 0 0 1 117.36 322.56 Tm <8EA9> Tj 1 0 0 1 125.52 322.56 Tm <93E0> Tj 1 0 0 1 133.92 322.80 Tm <8FE1> Tj 1 0 0 1 143.04 323.52 Tm <82CC> Tj 1 0 0 1 150.72 322.56 Tm <94AD> Tj 1 0 0 1 159.12 323.04 Tm <90B6> Tj 1 0 0 1 167.28 323.04 Tm <8CB4> Tj 1 0 0 1 175.92 323.04 Tm <88F6> Tj 1 0 0 1 186.00 323.52 Tm <82C6> Tj 1 0 0 1 194.88 323.52 Tm <82B5> Tj 1 0 0 1 202.56 323.76 Tm <82C4> Tj 1 0 0 1 210.96 323.04 Tm <91BD> Tj 1 0 0 1 219.12 323.04 Tm <9094> Tj 1 0 0 1 228.00 324.00 Tm <82CC> Tj 1 0 0 1 235.44 323.04 Tm <9776> Tj 1 0 0 1 39.60 308.88 Tm <88F6> Tj 1 0 0 1 48.24 309.84 Tm <82AA> Tj 1 0 0 1 56.88 309.36 Tm <8FE3> Tj 1 0 0 1 66.00 309.12 Tm <82B0> Tj 1 0 0 1 75.84 309.36 Tm <82E7> Tj 1 0 0 1 83.04 309.36 Tm <82EA> Tj 1 0 0 1 91.68 309.84 Tm <82C4> Tj 1 0 0 1 100.56 309.12 Tm <82AB> Tj 1 0 0 1 107.76 309.84 Tm <82BD> Tj 1 0 0 1 116.64 310.08 Tm <82AA> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 125.04 308.88 Tm <2C8AE1> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 142.56 309.36 Tm <9167> Tj 1 0 0 1 150.72 309.12 Tm <9044> Tj 1 0 0 1 159.60 310.08 Tm <82CD> Tj 1 0 0 1 167.28 309.36 Tm <91BC> Tj 1 0 0 1 176.16 310.32 Tm <82CC> Tj 1 0 0 1 184.32 309.60 Tm <9167> Tj 1 0 0 1 193.20 309.36 Tm <9044> Tj 1 0 0 1 203.76 310.08 Tm <82C6> Tj 1 0 0 1 210.72 309.60 Tm <88D9> Tj 1 0 0 1 219.84 310.08 Tm <82C8> Tj 1 0 0 1 229.44 309.84 Tm <82E8> Tj 0.00 Tc /F1 2.5 Tf 1 0 0 1 235.68 309.12 Tm <2C> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 39.36 295.44 Tm <8CF5> Tj 1 0 0 1 48.72 297.84 Tm <8347> Tj 1 0 0 1 57.60 296.16 Tm <836C> Tj 1 0 0 1 66.24 296.88 Tm <838B> Tj 1 0 0 1 75.12 296.40 Tm <834D> Tj 1 0 0 1 84.00 297.36 Tm <815B> Tj 1 0 0 1 91.44 296.64 Tm <82AA> Tj 1 0 0 1 99.36 295.68 Tm <904E> Tj 1 0 0 1 108.00 296.16 Tm <93FC> Tj 1 0 0 1 116.40 295.92 Tm <82B7> Tj 1 0 0 1 126.24 296.40 Tm <82E9> Tj 1 0 0 1 133.92 295.92 Tm <9167> Tj 1 0 0 1 142.56 295.92 Tm <9044> Tj 1 0 0 1 151.20 296.64 Tm <82C5> Tj 1 0 0 1 159.60 295.92 Tm <82A0> Tj 1 0 0 1 168.48 296.40 Tm <82E9> Tj 1 0 0 1 176.16 296.64 Tm <82BD> Tj 1 0 0 1 185.04 296.88 Tm <82DF> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 193.44 295.68 Tm <2C8AE1> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 210.72 296.16 Tm <9561> Tj 1 0 0 1 219.36 296.16 Tm <95CF> Tj 1 0 0 1 228.00 297.12 Tm <82CC> Tj 1 0 0 1 235.68 296.16 Tm <9561> Tj 1 0 0 1 39.36 281.76 Tm <91D4> Tj 1 0 0 1 48.48 282.24 Tm <82F0> Tj 1 0 0 1 56.88 282.00 Tm <8D6C> Tj 1 0 0 1 66.72 282.48 Tm <82A6> Tj 1 0 0 1 75.60 282.72 Tm <82E9> Tj 1 0 0 1 82.80 282.72 Tm <8FE3> Tj 1 0 0 1 91.44 282.96 Tm <82C5> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 99.36 282.00 Tm <2C8CF5> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 112.56 283.20 Tm <82CC> Tj 1 0 0 1 120.72 282.24 Tm <8965> Tj 1 0 0 1 129.60 282.24 Tm <8BBF> Tj 1 0 0 1 138.96 282.72 Tm <82F0> Tj 1 0 0 1 146.88 282.24 Tm <8D6C> Tj 1 0 0 1 155.04 282.48 Tm <97B6> Tj 1 0 0 1 163.92 283.20 Tm <82C9> Tj 1 0 0 1 171.84 282.96 Tm <93FC> Tj 1 0 0 1 180.48 282.72 Tm <82EA> Tj 1 0 0 1 190.08 282.96 Tm <82E9> Tj 1 0 0 1 198.00 282.72 Tm <954B> Tj 1 0 0 1 206.64 282.72 Tm <9776> Tj 1 0 0 1 215.52 283.44 Tm <82AA> Tj 1 0 0 1 223.92 282.72 Tm <82A0> Tj 1 0 0 1 232.80 283.20 Tm <82E9> Tj 0.00 Tc /F1 2.5 Tf 1 0 0 1 240.00 282.72 Tm <2E> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 39.36 268.32 Tm <93C1> Tj 1 0 0 1 48.72 269.28 Tm <82C9> Tj 1 0 0 1 58.08 268.56 Tm <8EA9> Tj 1 0 0 1 66.24 268.56 Tm <93E0> Tj 1 0 0 1 74.64 268.56 Tm <8FE1> Tj 1 0 0 1 82.80 268.56 Tm <94AD> Tj 1 0 0 1 91.20 268.56 Tm <8FC7> Tj 1 0 0 1 99.36 268.80 Tm <9776> Tj 1 0 0 1 108.24 268.80 Tm <88F6> Tj 1 0 0 1 117.12 269.52 Tm <82CC> Tj 1 0 0 1 125.28 269.76 Tm <88EA> Tj 1 0 0 1 134.40 270.24 Tm <82C2> Tj 1 0 0 1 144.24 269.52 Tm <82C6> Tj 1 0 0 1 152.40 269.52 Tm <82B5> Tj 1 0 0 1 159.60 269.76 Tm <82C4> Tj 1 0 0 1 167.52 268.80 Tm <8E87> Tj 1 0 0 1 175.92 268.80 Tm <8A4F> Tj 1 0 0 1 184.80 269.04 Tm <90FC> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 193.44 268.80 Tm <2C8B79> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 211.44 269.76 Tm <82D1> Tj 1 0 0 1 219.12 269.28 Tm <8BDF> Tj 1 0 0 1 227.52 269.28 Tm <8E87> Tj 1 0 0 1 235.92 269.28 Tm <8A4F> Tj 1 0 0 1 39.60 254.88 Tm <90FC> Tj 1 0 0 1 48.72 255.84 Tm <82CC> Tj 1 0 0 1 57.12 255.12 Tm <8965> Tj 1 0 0 1 65.76 255.12 Tm <8BBF> Tj 1 0 0 1 75.12 256.08 Tm <82CD> Tj 1 0 0 1 83.04 255.12 Tm <8A88> Tj 1 0 0 1 91.44 255.36 Tm <90AB> Tj 1 0 0 1 99.36 255.12 Tm <8E5F> Tj 1 0 0 1 107.76 255.12 Tm <9166> Tj 1 0 0 1 117.12 256.08 Tm <82CC> Tj 1 0 0 1 125.28 255.12 Tm <94AD> Tj 1 0 0 1 134.16 255.84 Tm <90B6> Tj 1 0 0 1 144.24 255.84 Tm <82C6> Tj 1 0 0 1 151.20 255.36 Tm <978D> Tj 1 0 0 1 159.60 255.84 Tm <82DD> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 167.52 255.12 Tm <2C96B3> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 184.56 255.36 Tm <8E8B> Tj 1 0 0 1 193.92 256.32 Tm <82C5> Tj 1 0 0 1 203.52 255.60 Tm <82AB> Tj 1 0 0 1 211.68 255.84 Tm <82C8> Tj 1 0 0 1 220.08 256.80 Tm <82A2> Tj 1 0 0 1 229.20 256.32 Tm <82C6> Tj 1 0 0 1 237.12 256.32 Tm <82B3> Tj 1 0 0 1 39.84 241.92 Tm <82EA> Tj 1 0 0 1 48.72 242.16 Tm <82C4> Tj 1 0 0 1 58.56 241.44 Tm <82AB> Tj 1 0 0 1 66.24 242.40 Tm <82BD> Tj 1 0 0 1 74.64 241.44 Tm <8142> Tj 1 0 0 1 83.52 241.92 Tm <82BB> Tj 1 0 0 1 92.64 242.88 Tm <82B1> Tj 1 0 0 1 99.84 242.40 Tm <82C5> Tj 1 0 0 1 108.00 241.68 Tm <967B> Tj 1 0 0 1 116.40 241.68 Tm <8CA4> Tj 1 0 0 1 125.52 241.92 Tm <8B86> Tj 1 0 0 1 134.88 242.64 Tm <82C9> Tj 1 0 0 1 143.28 242.64 Tm <82A8> Tj 1 0 0 1 151.68 242.88 Tm <82A2> Tj 1 0 0 1 159.84 242.64 Tm <82C4> Tj 1 0 0 1 168.24 242.88 Tm <82CD> Tj 1 0 0 1 177.84 243.60 Tm <8371> Tj 1 0 0 1 187.68 242.88 Tm <8367> Tj 1 0 0 1 193.92 242.40 Tm <9085> Tj 1 0 0 1 203.04 242.40 Tm <8FBB> Tj 1 0 0 1 210.96 242.40 Tm <91CC> Tj 1 0 0 1 220.08 242.64 Tm <82F0> Tj 1 0 0 1 227.76 241.92 Tm <8CF5> Tj 1 0 0 1 236.40 243.12 Tm <82AA> Tj 1 0 0 1 39.60 228.00 Tm <92CA> Tj 1 0 0 1 48.24 227.76 Tm <89DF> Tj 1 0 0 1 57.12 228.24 Tm <82B7> Tj 1 0 0 1 67.20 228.72 Tm <82E9> Tj 1 0 0 1 75.12 228.24 Tm <9286> Tj 1 0 0 1 83.04 228.48 Tm <9053> Tj 1 0 0 1 91.20 228.24 Tm <9594> Tj 1 0 0 1 101.04 228.72 Tm <82C6> Tj 1 0 0 1 108.00 228.48 Tm <93F8> Tj 1 0 0 1 116.64 228.24 Tm <8DCA> Tj 1 0 0 1 126.24 229.20 Tm <82C9> Tj 1 0 0 1 134.64 228.48 Tm <8942> Tj 1 0 0 1 144.00 228.96 Tm <82B3> Tj 1 0 0 1 151.44 228.72 Tm <82EA> Tj 1 0 0 1 159.84 229.20 Tm <82C4> Tj 1 0 0 1 168.24 229.44 Tm <82A2> Tj 1 0 0 1 177.12 228.96 Tm <82E9> Tj 1 0 0 1 184.80 228.72 Tm <8EFC> Tj 1 0 0 1 193.68 228.72 Tm <95D3> Tj 1 0 0 1 202.56 228.96 Tm <9594> Tj 1 0 0 1 211.92 229.44 Tm <82C9> Tj 1 0 0 1 219.84 228.72 Tm <95AA> Tj 1 0 0 1 227.76 228.96 Tm <8A84> Tj 1 0 0 1 237.36 229.44 Tm <82B5> Tj 1 0 0 1 40.08 215.28 Tm <82C4> Tj 1 0 0 1 49.20 214.56 Tm <9492> Tj 1 0 0 1 57.60 214.56 Tm <93E0> Tj 1 0 0 1 66.24 214.56 Tm <8FE1> Tj 1 0 0 1 74.88 214.56 Tm <94AD> Tj 1 0 0 1 83.28 214.80 Tm <8FC7> Tj 1 0 0 1 91.92 214.80 Tm <9668> Tj 1 0 0 1 100.08 214.80 Tm <8CE4> Tj 1 0 0 1 108.96 214.80 Tm <88F6> Tj 1 0 0 1 117.60 214.80 Tm <8E71> Tj 1 0 0 1 127.20 215.76 Tm <82CC> Tj 1 0 0 1 135.60 215.76 Tm <88EA> Tj 1 0 0 1 144.48 216.24 Tm <82C2> Tj 1 0 0 1 153.12 215.76 Tm <82C5> Tj 1 0 0 1 161.52 215.04 Tm <82A0> Tj 1 0 0 1 170.64 215.52 Tm <82E9> Tj 0.00 Tc /F1 11.5 Tf 1 0 0 1 180.00 215.76 Tm <47535482C9> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 210.72 216.48 Tm <82C2> Tj 1 0 0 1 219.84 216.24 Tm <82A2> Tj 1 0 0 1 228.00 216.00 Tm <82C4> Tj 1 0 0 1 236.16 215.52 Tm <8A88> Tj 1 0 0 1 39.84 201.12 Tm <90AB> Tj 1 0 0 1 48.96 201.36 Tm <82F0> Tj 1 0 0 1 57.12 201.12 Tm <91AA> Tj 1 0 0 1 66.24 201.12 Tm <92E8> Tj 1 0 0 1 76.08 201.84 Tm <82B5> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 83.28 200.88 Tm <2C9856> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 99.84 201.36 Tm <906C> Tj 1 0 0 1 108.24 201.36 Tm <90AB> Tj 1 0 0 1 117.60 201.36 Tm <9492> Tj 1 0 0 1 126.00 201.36 Tm <93E0> Tj 1 0 0 1 134.40 201.36 Tm <8FE1> Tj 1 0 0 1 143.04 201.60 Tm <9085> Tj 1 0 0 1 151.68 201.60 Tm <8FBB> Tj 1 0 0 1 159.36 201.36 Tm <91CC> Tj 1 0 0 1 169.20 202.08 Tm <82C6> Tj 1 0 0 1 175.92 201.84 Tm <93A7> Tj 1 0 0 1 185.28 201.60 Tm <96BE> Tj 1 0 0 1 193.92 201.84 Tm <9085> Tj 1 0 0 1 203.04 201.84 Tm <8FBB> Tj 1 0 0 1 211.20 201.60 Tm <91CC> Tj 1 0 0 1 221.04 202.32 Tm <82C6> Tj 1 0 0 1 228.48 202.56 Tm <82CC> Tj 1 0 0 1 236.16 202.08 Tm <94E4> Tj 1 0 0 1 39.60 187.44 Tm <8A72> Tj 1 0 0 1 48.24 187.44 Tm <8C9F> Tj 1 0 0 1 57.36 187.68 Tm <93A2> Tj 1 0 0 1 66.72 188.16 Tm <82F0> Tj 1 0 0 1 76.32 188.40 Tm <82B5> Tj 1 0 0 1 83.52 188.40 Tm <82BD> Tj 1 0 0 1 91.44 187.68 Tm <8142> Tj 0.00 Tc /F1 13.0 Tf 1 0 0 1 110.88 167.52 Tm <494920> Tj 5.76 Tc /F1 10.5 Tf 1 0 0 1 131.76 166.56 Tm <8EC0> Tj 1 0 0 1 142.08 166.56 Tm <8CB1> Tj 1 0 0 1 152.64 166.80 Tm <95FB> Tj 1 0 0 1 162.96 167.04 Tm <9640> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 48.48 146.88 Tm <8E8E> Tj 1 0 0 1 57.60 147.12 Tm <97BF> Tj 1 0 0 1 67.92 147.60 Tm <82C6> Tj 1 0 0 1 76.56 147.60 Tm <82B5> Tj 1 0 0 1 83.76 147.84 Tm <82C4> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 91.68 146.88 Tm <2C9153> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 108.24 147.12 Tm <9345> Tj 1 0 0 1 118.08 147.60 Tm <82B3> Tj 1 0 0 1 126.00 147.60 Tm <82EA> Tj 1 0 0 1 134.88 148.08 Tm <82BD> Tj 1 0 0 1 142.80 147.36 Tm <939C> Tj 1 0 0 1 151.68 147.36 Tm <9441> Tj 1 0 0 1 159.60 147.36 Tm <9561> Tj 1 0 0 1 168.48 147.84 Tm <82F0> Tj 1 0 0 1 176.40 147.60 Tm <8D87> Tj 1 0 0 1 185.04 147.60 Tm <95B9> Tj 1 0 0 1 195.36 148.32 Tm <82B5> Tj 1 0 0 1 203.52 148.32 Tm <82C4> Tj 1 0 0 1 211.92 148.56 Tm <82A2> Tj 1 0 0 1 220.56 148.08 Tm <82C8> Tj 1 0 0 1 228.72 148.80 Tm <82A2> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 236.40 148.32 Tm <3433> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 39.84 133.44 Tm <8DCE> Tj 1 0 0 1 48.96 134.40 Tm <82A9> Tj 1 0 0 1 59.04 133.92 Tm <82E7> Tj 0.00 Tc 1 0 0 1 66.24 134.40 Tm <38328DCE> Tj 5.76 Tc 1 0 0 1 84.48 134.16 Tm <82DC> Tj 1 0 0 1 92.16 134.64 Tm <82C5> Tj 1 0 0 1 100.32 134.88 Tm <82CC> Tj 1 0 0 1 108.00 133.68 Tm <8CE3> Tj 1 0 0 1 116.88 133.92 Tm <9458> Tj 1 0 0 1 125.76 134.16 Tm <89BA> Tj 1 0 0 1 134.40 134.16 Tm <8DAC> Tj 1 0 0 1 143.04 133.92 Tm <91F7> Tj 1 0 0 1 151.92 134.40 Tm <82F0> Tj 1 0 0 1 159.84 134.40 Tm <8EE5> Tj 1 0 0 1 168.00 134.16 Tm <91CC> Tj 1 0 0 1 178.08 134.64 Tm <82C6> Tj 1 0 0 1 186.48 134.88 Tm <82B5> Tj 1 0 0 1 194.16 134.88 Tm <82BD> Tj 1 0 0 1 202.80 134.40 Tm <9856> Tj 1 0 0 1 211.44 134.40 Tm <906C> Tj 1 0 0 1 220.08 134.40 Tm <90AB> Tj 1 0 0 1 229.20 134.40 Tm <8EA9> Tj 1 0 0 1 236.88 134.40 Tm <93E0> Tj 1 0 0 1 40.08 120.00 Tm <8FE1> Tj 1 0 0 1 48.96 120.24 Tm <9085> Tj 1 0 0 1 58.08 120.24 Tm <8FBB> Tj 1 0 0 1 66.24 120.24 Tm <91CC> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 75.36 120.72 Tm <313597E1> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 93.36 120.72 Tm <82C6> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 100.08 120.00 Tm <2C9245> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 117.36 120.24 Tm <8950> Tj 1 0 0 1 126.00 120.48 Tm <9085> Tj 1 0 0 1 135.12 120.48 Tm <8FBB> Tj 1 0 0 1 143.28 120.48 Tm <91CC> Tj 0.00 Tc /F1 10.0 Tf 1 0 0 1 151.68 120.24 Tm <2C8B79> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 168.72 121.20 Tm <82D1> Tj 1 0 0 1 176.40 120.24 Tm <9345> Tj 1 0 0 1 185.76 120.72 Tm <8F6F> Tj 1 0 0 1 194.40 120.72 Tm <8AE1> Tj 1 0 0 1 202.80 120.72 Tm <8B85> Tj 1 0 0 1 212.64 121.44 Tm <82E6> Tj 1 0 0 1 222.00 121.20 Tm <82E8> Tj 1 0 0 1 228.24 120.72 Tm <93BE> Tj 1 0 0 1 237.84 121.20 Tm <82E7> Tj 1 0 0 1 40.32 106.80 Tm <82EA> Tj 1 0 0 1 48.96 107.28 Tm <82BD> Tj 1 0 0 1 57.60 106.80 Tm <93A7> Tj 1 0 0 1 66.96 106.56 Tm <96BE> Tj 1 0 0 1 75.12 106.80 Tm <9085> Tj 1 0 0 1 84.00 106.80 Tm <8FBB> Tj 1 0 0 1 91.92 106.80 Tm <91CC> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 102.00 107.28 Tm <3897E1> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 117.60 107.28 Tm <82F0> Tj 1 0 0 1 126.00 107.04 Tm <9770> Tj 1 0 0 1 135.36 108.00 Tm <82A2> Tj 1 0 0 1 143.52 107.52 Tm <82BD> Tj 1 0 0 1 151.68 106.80 Tm <8142> Tj 1 0 0 1 161.28 108.00 Tm <82B1> Tj 1 0 0 1 168.24 107.28 Tm <82EA> Tj 1 0 0 1 178.08 107.52 Tm <82E7> Tj 1 0 0 1 185.76 108.00 Tm <82CC> Tj 1 0 0 1 194.40 107.28 Tm <9085> Tj 1 0 0 1 203.52 107.28 Tm <8FBB> Tj 1 0 0 1 211.44 107.28 Tm <91CC> Tj 1 0 0 1 220.80 108.24 Tm <82CD> Tj 1 0 0 1 228.48 107.52 Tm <89C2> Tj 1 0 0 1 236.64 107.28 Tm <8B79> Tj 1 0 0 1 40.32 93.12 Tm <9349> Tj 1 0 0 1 49.44 93.84 Tm <82C9> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 57.84 92.88 Tm <2C93F8> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 75.12 93.12 Tm <8DCA> Tj 1 0 0 1 83.76 93.36 Tm <9046> Tj 1 0 0 1 91.92 93.12 Tm <9166> Tj 1 0 0 1 100.56 93.60 Tm <82F0> Tj 1 0 0 1 108.24 93.36 Tm <8EE6> Tj 1 0 0 1 119.28 93.84 Tm <82E8> Tj 1 0 0 1 126.24 93.36 Tm <8F9C> Tj 1 0 0 1 136.08 93.60 Tm <82AB> Tj 1 0 0 1 143.28 93.60 Tm <8E67> Tj 1 0 0 1 151.68 93.60 Tm <9770> Tj 1 0 0 1 160.80 94.08 Tm <82DC> Tj 1 0 0 1 168.48 94.32 Tm <82C5> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 177.60 95.04 Tm <2D3230818E> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 203.76 94.56 Tm <82C9> Tj 1 0 0 1 211.44 93.84 Tm <95DB> Tj 1 0 0 1 219.84 93.60 Tm <91B6> Tj 1 0 0 1 229.68 94.32 Tm <82B3> Tj 1 0 0 1 236.88 94.08 Tm <82EA> Tj 1 0 0 1 40.32 80.40 Tm <82BD> Tj 1 0 0 1 50.16 79.92 Tm <82E0> Tj 1 0 0 1 58.32 80.64 Tm <82CC> Tj 1 0 0 1 67.20 80.16 Tm <82F0> Tj 1 0 0 1 75.36 79.92 Tm <8E67> Tj 1 0 0 1 83.76 79.92 Tm <9770> Tj 1 0 0 1 93.36 80.40 Tm <82B5> Tj 1 0 0 1 100.32 80.64 Tm <82BD> Tj 1 0 0 1 108.48 79.92 Tm <8142> Tj 1 0 0 1 48.96 66.24 Tm <95FB> Tj 1 0 0 1 58.08 66.48 Tm <9640> Tj 1 0 0 1 68.64 66.96 Tm <82C6> Tj 1 0 0 1 77.04 67.20 Tm <82B5> Tj 1 0 0 1 84.96 67.20 Tm <82C4> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 92.64 66.24 Tm <2C9085> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 109.92 66.72 Tm <8FBB> Tj 1 0 0 1 118.32 66.72 Tm <91CC> Tj 1 0 0 1 127.92 66.96 Tm <82F0> Tj 1 0 0 1 137.52 67.68 Tm <834B> Tj 1 0 0 1 146.40 67.68 Tm <8389> Tj 1 0 0 1 154.56 68.16 Tm <8358> Tj 1 0 0 1 161.76 66.72 Tm <94C2> Tj 1 0 0 1 171.12 67.68 Tm <82C9> Tj 1 0 0 1 179.04 66.96 Tm <9275> Tj 1 0 0 1 189.36 66.96 Tm <82AB> Tj 1 0 0 1 197.76 66.96 Tm <8CC5> Tj 1 0 0 1 206.40 66.96 Tm <92E8> Tj 1 0 0 1 216.72 67.68 Tm <82B5> Tj 1 0 0 1 223.92 66.96 Tm <92BC> Tj 1 0 0 1 232.56 66.96 Tm <8C61> Tj 0.00 Tc /F1 7.0 Tf 1 0 0 1 240.96 67.68 Tm <36> Tj 0.00 Tc /F1 12.0 Tf 1 0 0 1 266.40 540.00 Tm <6D6D82CC> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 292.56 541.44 Tm <8370> Tj 1 0 0 1 301.68 540.72 Tm <8393> Tj 1 0 0 1 309.36 540.24 Tm <8360> Tj 1 0 0 1 318.72 540.24 Tm <8383> Tj 1 0 0 1 327.12 540.96 Tm <815B> Tj 1 0 0 1 335.52 539.76 Tm <82F0> Tj 1 0 0 1 344.16 539.52 Tm <9396> Tj 1 0 0 1 352.80 540.24 Tm <82C4> Tj 0.00 Tc /F1 10.0 Tf 1 0 0 1 360.72 539.28 Tm <2C92E4> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 377.28 539.76 Tm <9381> Tj 1 0 0 1 385.92 540.48 Tm <82C5> Tj 1 0 0 1 394.32 540.00 Tm <82BB> Tj 1 0 0 1 403.20 540.00 Tm <82EA> Tj 1 0 0 1 412.56 540.48 Tm <82C9> Tj 1 0 0 1 420.24 539.76 Tm <9359> Tj 1 0 0 1 429.84 540.48 Tm <82C1> Tj 1 0 0 1 437.28 540.48 Tm <82C4> Tj 1 0 0 1 445.44 540.00 Tm <9085> Tj 1 0 0 1 453.84 540.00 Tm <8FBB> Tj 1 0 0 1 462.00 540.00 Tm <91CC> Tj 1 0 0 1 266.88 525.60 Tm <9458> Tj 1 0 0 1 276.00 526.08 Tm <82F0> Tj 1 0 0 1 284.16 525.84 Tm <90D8> Tj 1 0 0 1 292.32 525.84 Tm <8A4A> Tj 1 0 0 1 301.68 526.56 Tm <82B5> Tj 1 0 0 1 309.12 526.56 Tm <82BD> Tj 1 0 0 1 318.00 526.80 Tm <82CC> Tj 1 0 0 1 326.64 526.56 Tm <82BF> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 335.04 525.60 Tm <2C907D> Tj /F1 8.5 Tf 1 0 0 1 354.72 526.80 Tm <3182C9> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 368.64 526.32 Tm <8EA6> Tj 1 0 0 1 377.28 526.32 Tm <82B7> Tj 1 0 0 1 386.64 526.80 Tm <82E6> Tj 1 0 0 1 396.24 526.56 Tm <82A4> Tj 1 0 0 1 403.68 527.04 Tm <82C9> Tj 1 0 0 1 411.60 526.32 Tm <8A6A> Tj 1 0 0 1 421.92 526.80 Tm <82C6> Tj 1 0 0 1 428.64 526.32 Tm <94E7> Tj 1 0 0 1 437.04 526.32 Tm <8EBF> Tj 1 0 0 1 445.68 526.80 Tm <82F0> Tj 1 0 0 1 453.84 526.80 Tm <82BB> Tj 1 0 0 1 462.48 527.52 Tm <82CC> Tj 1 0 0 1 267.84 512.64 Tm <82DC> Tj 1 0 0 1 276.72 512.64 Tm <82DC> Tj 1 0 0 1 284.16 512.16 Tm <91C5> Tj 1 0 0 1 293.04 512.88 Tm <82BF> Tj 1 0 0 1 300.48 512.40 Tm <94B2> Tj 1 0 0 1 310.08 512.40 Tm <82AB> Tj 0.00 Tc /F1 7.0 Tf 1 0 0 1 317.28 511.92 Tm <2C82DC> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 330.96 513.12 Tm <82BD> Tj 1 0 0 1 339.84 512.88 Tm <82BB> Tj 1 0 0 1 348.72 513.36 Tm <82CC> Tj 1 0 0 1 356.64 512.88 Tm <89BA> Tj 1 0 0 1 365.28 513.36 Tm <82CC> Tj 1 0 0 1 373.20 512.88 Tm <9085> Tj 1 0 0 1 381.60 512.64 Tm <8FBB> Tj 1 0 0 1 389.76 512.64 Tm <91CC> Tj 1 0 0 1 398.40 512.64 Tm <9458> Tj 1 0 0 1 407.76 513.12 Tm <82F0> Tj 1 0 0 1 415.92 512.88 Tm <92E4> Tj 1 0 0 1 424.80 513.12 Tm <9381> Tj 1 0 0 1 433.20 513.60 Tm <82C5> Tj 1 0 0 1 441.12 513.12 Tm <90D8> Tj 1 0 0 1 449.52 512.88 Tm <8A4A> Tj 1 0 0 1 459.12 513.60 Tm <82B5> Tj 0.00 Tc /F1 2.5 Tf 1 0 0 1 466.32 512.64 Tm <2C> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 266.88 498.72 Tm <8AAE> Tj 1 0 0 1 275.52 498.72 Tm <9153> Tj 1 0 0 1 284.88 499.68 Tm <82C9> Tj 1 0 0 1 292.56 498.72 Tm <95AA> Tj 1 0 0 1 300.72 498.96 Tm <8A84> Tj 1 0 0 1 310.08 499.44 Tm <82B5> Tj 1 0 0 1 317.76 499.68 Tm <82C4> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 326.40 498.48 Tm <2C9085> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 344.40 499.20 Tm <8FBB> Tj 1 0 0 1 352.32 498.96 Tm <91CC> Tj 1 0 0 1 361.20 499.44 Tm <82F0> Tj 1 0 0 1 369.36 498.96 Tm <9286> Tj 1 0 0 1 377.04 499.44 Tm <9053> Tj 1 0 0 1 385.44 499.20 Tm <9594> Tj 1 0 0 1 395.76 499.68 Tm <82C6> Tj 1 0 0 1 403.20 499.20 Tm <8EFC> Tj 1 0 0 1 411.84 499.44 Tm <95D3> Tj 1 0 0 1 420.48 499.68 Tm <9594> Tj 1 0 0 1 429.36 500.16 Tm <82CC> Tj 1 0 0 1 437.04 500.64 Tm <93F1> Tj 1 0 0 1 445.44 500.64 Tm <82C2> Tj 1 0 0 1 454.08 500.40 Tm <82CC> Tj 1 0 0 1 463.44 500.64 Tm <8375> Tj 1 0 0 1 268.80 486.96 Tm <838D> Tj 1 0 0 1 277.68 485.52 Tm <8362> Tj 1 0 0 1 285.36 486.24 Tm <834E> Tj 1 0 0 1 294.00 485.76 Tm <82C6> Tj 1 0 0 1 302.16 486.00 Tm <82B5> Tj 1 0 0 1 309.60 486.24 Tm <82BD> Tj 1 0 0 1 317.76 485.28 Tm <8142> Tj 1 0 0 1 326.88 485.28 Tm <95AA> Tj 1 0 0 1 335.76 485.52 Tm <8A84> Tj 1 0 0 1 346.08 486.24 Tm <82B5> Tj 1 0 0 1 353.52 486.24 Tm <82BD> Tj 1 0 0 1 361.92 485.76 Tm <9085> Tj 1 0 0 1 370.56 485.76 Tm <8FBB> Tj 1 0 0 1 378.48 485.76 Tm <91CC> Tj 1 0 0 1 387.60 486.00 Tm <82F0> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 396.00 486.24 Tm <35306D4D2C704820372E3882CC> Tj /F1 8.5 Tf 1 0 0 1 266.88 472.80 Tm <70684F737068617465206275666665722032726E6C815D> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 366.24 472.80 Tm <82C4> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 368.88 472.80 Tm <7D686F6E81A1> Tj /F1 9.5 Tf 1 0 0 1 393.12 472.80 Tm <6F67656E697A6582B5> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 440.40 473.04 Tm <82BD> Tj 1 0 0 1 451.68 473.28 Tm <82CC> Tj 0.00 Tc /F1 8.5 Tf 1 0 0 1 456.24 473.76 Tm <2982BF> Tj 1 0 0 1 269.28 458.88 Tm <34818E> Tj /F1 9.0 Tf 1 0 0 1 284.64 458.88 Tm <31322C30303072706D82C9> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 336.72 459.12 Tm <82C4> Tj 0.00 Tc 1 0 0 1 345.12 459.12 Tm <333095AA> Tj 3.84 Tc 1 0 0 1 362.16 458.64 Tm <8AD4> Tj 1 0 0 1 370.08 458.64 Tm <8993> Tj 1 0 0 1 378.24 458.88 Tm <9053> Tj 1 0 0 1 388.08 459.36 Tm <82B5> Tj 0.00 Tc /F1 10.0 Tf 1 0 0 1 395.52 458.40 Tm <2C82BB> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 412.56 459.60 Tm <82CC> Tj 1 0 0 1 420.48 459.36 Tm <8FE3> Tj 1 0 0 1 429.12 458.64 Tm <90B4> Tj 1 0 0 1 437.76 459.12 Tm <82F0> Tj 1 0 0 1 445.44 459.12 Tm <9085> Tj 1 0 0 1 454.08 458.88 Tm <8FBB> Tj 1 0 0 1 462.00 458.88 Tm <91CC> Tj 1 0 0 1 267.36 444.72 Tm <9286> Tj 1 0 0 1 276.72 445.68 Tm <82CC> Tj 1 0 0 1 286.08 445.68 Tm <834F> Tj 1 0 0 1 294.00 446.16 Tm <838B> Tj 1 0 0 1 303.36 445.92 Tm <835E> Tj 1 0 0 1 311.52 445.92 Tm <8360> Tj 1 0 0 1 320.64 445.92 Tm <8349> Tj 1 0 0 1 330.24 446.40 Tm <8393> Tj 1 0 0 1 338.40 445.44 Tm <82E2> Tj 1 0 0 1 347.28 444.96 Tm <91BC> Tj 1 0 0 1 356.64 445.92 Tm <82CC> Tj 1 0 0 1 364.56 444.96 Tm <92E1> Tj 1 0 0 1 373.44 444.96 Tm <95AA> Tj 1 0 0 1 381.84 444.96 Tm <8E71> Tj 1 0 0 1 390.48 445.20 Tm <8AD2> Tj 1 0 0 1 399.84 445.20 Tm <8CB3> Tj 1 0 0 1 408.96 445.20 Tm <95A8> Tj 1 0 0 1 418.32 445.20 Tm <8EBF> Tj 1 0 0 1 427.44 445.68 Tm <82F0> Tj 1 0 0 1 435.84 445.20 Tm <8F9C> Tj 1 0 0 1 446.16 445.68 Tm <82AD> Tj 1 0 0 1 453.36 445.92 Tm <82BD> Tj 1 0 0 1 462.72 446.16 Tm <82DF> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 266.88 431.76 Tm <63656E747269636F6E20> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 305.04 433.68 Tm <8742> Tj 0.00 Tc /F1 10.0 Tf 1 0 0 1 315.60 431.52 Tm <28416D69636F6E8ED0> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 361.20 431.52 Tm <90BB> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 369.60 431.52 Tm <2982F0> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 385.68 431.76 Tm <9770> Tj 1 0 0 1 395.04 432.72 Tm <82A2> Tj 1 0 0 1 403.68 432.48 Tm <82C4> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 412.08 431.28 Tm <2C2032947B> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 438.00 432.48 Tm <82C9> Tj 1 0 0 1 445.44 431.76 Tm <945A> Tj 1 0 0 1 453.60 432.00 Tm <8F6B> Tj 1 0 0 1 463.68 432.48 Tm <82B5> Tj 1 0 0 1 267.36 418.32 Tm <82BD> Tj 1 0 0 1 277.20 417.84 Tm <82E0> Tj 1 0 0 1 284.88 418.56 Tm <82CC> Tj 1 0 0 1 293.04 418.08 Tm <82F0> Tj 1 0 0 1 300.96 417.84 Tm <9770> Tj 1 0 0 1 309.84 418.80 Tm <82A2> Tj 1 0 0 1 318.00 418.56 Tm <82BD> Tj 1 0 0 1 326.64 417.84 Tm <8142> Tj 0.00 Tc /F1 11.5 Tf 1 0 0 1 331.68 418.56 Tm <4753548A88> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 361.44 418.08 Tm <90AB> Tj 1 0 0 1 369.60 418.32 Tm <91AA> Tj 1 0 0 1 377.76 418.08 Tm <92E8> Tj 1 0 0 1 386.64 419.04 Tm <82CD> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 397.20 419.04 Tm <486162696782E7> Tj /F1 5.5 Tf 1 0 0 1 432.24 422.16 Tm <372982CC> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 445.44 418.56 Tm <95FB> Tj 1 0 0 1 453.60 418.56 Tm <9640> Tj 1 0 0 1 462.96 419.28 Tm <82C9> Tj 1 0 0 1 267.12 404.40 Tm <88CB> Tj 1 0 0 1 278.64 404.64 Tm <82E8> Tj 0.00 Tc /F1 6.5 Tf 1 0 0 1 285.12 403.92 Tm <2C31815D> Tj 1 0 0 1 299.76 404.88 Tm <63686C6F726F815D> Tj /F1 8.0 Tf 1 0 0 1 327.60 405.12 Tm <322C342D64696E6974726F62656E7A656E82F0> Tj 3.84 Tc 1 0 0 1 406.08 404.88 Tm <8AEE> Tj 1 0 0 1 415.44 404.64 Tm <8EBF> Tj 1 0 0 1 426.00 405.60 Tm <82C6> Tj 1 0 0 1 434.40 405.60 Tm <82B5> Tj 1 0 0 1 442.56 405.60 Tm <82C4> Tj 0.00 Tc /F1 12.0 Tf 1 0 0 1 452.16 405.60 Tm <475354> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 267.84 391.68 Tm <82CC> Tj 1 0 0 1 276.00 390.96 Tm <8A88> Tj 1 0 0 1 284.64 390.96 Tm <90AB> Tj 1 0 0 1 292.80 390.96 Tm <926C> Tj 1 0 0 1 301.68 391.20 Tm <82F0> Tj 1 0 0 1 309.84 391.20 Tm <91AA> Tj 1 0 0 1 318.48 390.96 Tm <92E8> Tj 1 0 0 1 329.04 391.68 Tm <82B5> Tj 1 0 0 1 336.72 391.68 Tm <82BD> Tj 1 0 0 1 345.36 390.96 Tm <8142> Tj 1 0 0 1 353.76 390.96 Tm <9260> Tj 1 0 0 1 363.12 391.20 Tm <9492> Tj 1 0 0 1 370.56 391.20 Tm <92E8> Tj 1 0 0 1 378.96 391.44 Tm <97CA> Tj 1 0 0 1 388.32 392.16 Tm <82CD> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 398.88 391.92 Tm <42726164666F72649640> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 445.92 392.16 Tm <82C9> Tj 1 0 0 1 453.60 391.44 Tm <8F5D> Tj 1 0 0 1 463.68 392.16 Tm <82C1> Tj 1 0 0 1 267.60 378.00 Tm <82BD> Tj 1 0 0 1 276.00 377.04 Tm <8142> Tj 1 0 0 1 284.64 377.52 Tm <8A88> Tj 1 0 0 1 292.80 377.52 Tm <90AB> Tj 1 0 0 1 300.96 377.28 Tm <926C> Tj 1 0 0 1 309.84 378.24 Tm <82CD> Tj 1 0 0 1 317.76 377.52 Tm <89C2> Tj 1 0 0 1 326.64 377.52 Tm <976E> Tj 1 0 0 1 335.52 377.76 Tm <90AB> Tj 1 0 0 1 344.16 377.52 Tm <9260> Tj 1 0 0 1 353.76 377.52 Tm <9492> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 362.88 378.24 Tm <6D6782A0> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 385.68 378.24 Tm <82BD> Tj 1 0 0 1 396.24 378.00 Tm <82E8> Tj 1 0 0 1 403.44 378.72 Tm <82CC> Tj 1 0 0 1 412.32 378.00 Tm <8B7A> Tj 1 0 0 1 420.24 377.76 Tm <8CF5> Tj 1 0 0 1 428.88 377.76 Tm <9378> Tj 0.00 Tc /F1 8.5 Tf 1 0 0 1 438.48 378.00 Tm <283334306E6D29> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 267.84 364.56 Tm <82CC> Tj 1 0 0 1 276.24 363.60 Tm <95CF> Tj 1 0 0 1 284.40 363.84 Tm <89BB> Tj 1 0 0 1 293.28 364.08 Tm <82F0> Tj 1 0 0 1 301.44 363.84 Tm <8D91> Tj 1 0 0 1 309.12 363.84 Tm <8DDB> Tj 1 0 0 1 317.76 363.84 Tm <9250> Tj 1 0 0 1 326.64 364.08 Tm <88CA> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 340.56 364.08 Tm <286D552982C5> Tj 3.84 Tc /F1 8.0 Tf 1 0 0 1 374.64 364.08 Tm <955C> Tj 1 0 0 1 383.28 364.80 Tm <82ED> Tj 1 0 0 1 393.36 364.80 Tm <82B5> Tj 1 0 0 1 401.04 364.80 Tm <82BD> Tj 1 0 0 1 409.68 364.32 Tm <8142> Tj 0.00 Tc /F1 11.5 Tf 1 0 0 1 336.00 343.92 Tm <49494920> Tj /F1 10.0 Tf 1 0 0 1 360.72 342.96 Tm <8C8B> Tj /F1 15.0 Tf 1 0 0 1 371.04 342.96 Tm <2020> Tj /F1 10.0 Tf 1 0 0 1 392.16 343.20 Tm <89CA> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 276.24 323.52 Tm <9856> Tj 1 0 0 1 284.88 323.52 Tm <906C> Tj 1 0 0 1 293.04 323.52 Tm <90AB> Tj 1 0 0 1 302.16 323.52 Tm <9492> Tj 1 0 0 1 309.84 323.52 Tm <93E0> Tj 1 0 0 1 318.00 323.28 Tm <8FE1> Tj 1 0 0 1 327.12 323.76 Tm <9085> Tj 1 0 0 1 336.24 323.76 Tm <8FBB> Tj 1 0 0 1 344.40 323.76 Tm <91CC> Tj 0.00 Tc /F1 7.5 Tf 1 0 0 1 353.28 324.24 Tm <313597E1> Tj /F1 10.0 Tf 1 0 0 1 369.60 323.52 Tm <2C8B79> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 386.64 324.48 Tm <82D1> Tj 1 0 0 1 394.56 324.00 Tm <93A7> Tj 1 0 0 1 403.92 324.00 Tm <96BE> Tj 1 0 0 1 412.80 324.00 Tm <9085> Tj 1 0 0 1 421.44 324.00 Tm <8FBB> Tj 1 0 0 1 429.36 324.00 Tm <91CC> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 439.44 324.72 Tm <3897E1> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 454.56 324.96 Tm <82CC> Tj 1 0 0 1 462.96 324.00 Tm <9286> Tj 1 0 0 1 267.60 310.08 Tm <9053> Tj 1 0 0 1 276.24 310.08 Tm <9594> Tj 1 0 0 1 286.32 310.56 Tm <82C6> Tj 1 0 0 1 293.04 310.08 Tm <8EFC> Tj 1 0 0 1 301.20 310.08 Tm <95D3> Tj 1 0 0 1 309.36 310.08 Tm <9594> Tj 1 0 0 1 318.96 310.80 Tm <82CC> Tj 0.00 Tc /F1 11.5 Tf 1 0 0 1 329.28 310.56 Tm <4753548A88> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 359.28 310.32 Tm <90AB> Tj 1 0 0 1 368.16 310.56 Tm <82F0> Tj 1 0 0 1 375.84 310.56 Tm <91AA> Tj 1 0 0 1 384.48 310.32 Tm <92E8> Tj 1 0 0 1 394.80 311.04 Tm <82B5> Tj 1 0 0 1 402.72 311.04 Tm <82BD> Tj 1 0 0 1 411.36 310.32 Tm <8C8B> Tj 1 0 0 1 420.24 310.56 Tm <89CA> Tj 1 0 0 1 429.12 310.80 Tm <82F0> Tj 1 0 0 1 437.04 310.56 Tm <955C> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 447.84 311.28 Tm <3182C9> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 462.72 310.80 Tm <8EA6> Tj 1 0 0 1 267.60 296.40 Tm <82B7> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 276.48 296.40 Tm <2E93A7> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 292.08 296.64 Tm <96BE> Tj 1 0 0 1 300.00 296.88 Tm <9085> Tj 1 0 0 1 308.40 296.64 Tm <8FBB> Tj 1 0 0 1 316.32 296.64 Tm <91CC> Tj 1 0 0 1 325.68 297.36 Tm <82CC> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 336.24 297.36 Tm <4753548A88> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 365.52 296.88 Tm <90AB> Tj 1 0 0 1 374.16 297.84 Tm <82CD> Tj 1 0 0 1 382.32 296.88 Tm <9286> Tj 1 0 0 1 390.48 297.36 Tm <9053> Tj 1 0 0 1 399.36 297.12 Tm <9594> Tj 0.00 Tc /F1 8.5 Tf 1 0 0 1 408.72 296.88 Tm <28432982C5> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 431.52 298.08 Tm <82CD> Tj 0.00 Tc /F1 8.5 Tf 1 0 0 1 439.20 296.88 Tm <2C382E35348E6D> Tj /F1 9.5 Tf 1 0 0 1 267.60 283.68 Tm <342E3033286D552F6D672070726F7465696E2982C5> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 372.72 283.44 Tm <82A0> Tj 1 0 0 1 382.32 283.68 Tm <82E8> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 388.80 283.20 Tm <2C8EFC> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 406.56 283.68 Tm <95D3> Tj 1 0 0 1 415.20 283.68 Tm <9594> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 428.64 283.68 Tm <28502982C5> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 454.80 284.64 Tm <82CD> Tj 0.00 Tc /F1 2.5 Tf 1 0 0 1 462.72 283.44 Tm <2C> Tj /F1 7.5 Tf 1 0 0 1 268.08 270.00 Tm <31392E3733817D> Tj /F1 9.5 Tf 1 0 0 1 297.12 270.24 Tm <362E3537286D552F6D672070726F7465696E2982C5> Tj 5.76 Tc /F1 8.0 Tf 1 0 0 1 402.72 270.00 Tm <82A0> Tj 1 0 0 1 412.08 270.72 Tm <82C1> Tj 1 0 0 1 419.76 270.72 Tm <82BD> Tj 1 0 0 1 427.92 270.00 Tm <8142> Tj 7.68 Tc /F1 7.5 Tf 1 0 0 1 366.48 115.44 Tm <82BB> Tj 1 0 0 1 374.64 115.68 Tm <82EA> Tj 1 0 0 1 383.28 115.44 Tm <82BC> Tj 1 0 0 1 390.00 121.92 Tm <814D> Tj 1 0 0 1 392.16 115.68 Tm <82EA> Tj 1 0 0 1 402.00 115.68 Tm <82F0> Tj 0.00 Tc /F1 9.0 Tf 1 0 0 1 411.12 116.40 Tm <686F6D6F67656E697A65> Tj 7.68 Tc /F1 7.5 Tf 1 0 0 1 277.20 100.56 Tm <907D> Tj 0.00 Tc /F1 10.5 Tf 1 0 0 1 286.80 101.04 Tm <31203C9085> Tj 7.68 Tc /F1 7.5 Tf 1 0 0 1 315.36 100.56 Tm <8FBB> Tj 1 0 0 1 323.04 100.32 Tm <91CC> Tj 1 0 0 1 331.44 101.28 Tm <82CC> Tj 1 0 0 1 339.36 100.32 Tm <91C5> Tj 1 0 0 1 347.76 101.04 Tm <82BF> Tj 1 0 0 1 354.96 100.56 Tm <94B2> Tj 1 0 0 1 363.60 100.56 Tm <82AB> Tj 1 0 0 1 370.08 100.56 Tm <9640> Tj 0.00 Tc /F1 11.0 Tf 1 0 0 1 377.04 100.56 Tm <3E2E9085> Tj 7.68 Tc /F1 7.5 Tf 1 0 0 1 401.76 100.56 Tm <8FBB> Tj 1 0 0 1 409.44 100.32 Tm <91CC> Tj 1 0 0 1 417.84 100.80 Tm <82F0> Tj 1 0 0 1 427.68 101.28 Tm <8367> Tj 1 0 0 1 434.16 102.00 Tm <838C> Tj 1 0 0 1 441.60 101.52 Tm <8374> Tj 1 0 0 1 449.52 101.28 Tm <8342> Tj 1 0 0 1 456.48 101.76 Tm <8393> Tj 1 0 0 1 284.88 89.76 Tm <82C5> Tj 1 0 0 1 292.32 89.04 Tm <91C5> Tj 1 0 0 1 300.24 89.52 Tm <82BF> Tj 1 0 0 1 307.20 89.04 Tm <94B2> Tj 1 0 0 1 316.56 89.28 Tm <82AD> Tj 1 0 0 1 324.48 89.52 Tm <82C6> Tj 1 0 0 1 332.40 89.04 Tm <82AB> Tj 0.00 Tc /F1 9.5 Tf 1 0 0 1 339.36 88.80 Tm <2C9085> Tj 7.68 Tc /F1 7.5 Tf 1 0 0 1 355.44 89.28 Tm <8FBB> Tj 1 0 0 1 362.40 89.04 Tm <91CC> Tj 1 0 0 1 370.56 89.76 Tm <82CC> Tj 1 0 0 1 378.48 90.00 Tm <834A> Tj 1 0 0 1 386.16 90.00 Tm <8376> Tj 1 0 0 1 393.60 90.48 Tm <835A> Tj 1 0 0 1 401.76 90.48 Tm <838B> Tj 1 0 0 1 409.68 89.76 Tm <82AA> Tj 1 0 0 1 417.60 89.04 Tm <8AAA> Tj 1 0 0 1 426.48 89.04 Tm <82AB> Tj 1 0 0 1 432.72 89.28 Tm <8D9E> Tj 1 0 0 1 441.12 89.52 Tm <82DC> Tj 1 0 0 1 448.08 89.28 Tm <82EA> Tj 1 0 0 1 456.00 89.28 Tm <82C8> Tj 1 0 0 1 285.12 78.72 Tm <82A2> Tj 1 0 0 1 293.76 78.48 Tm <82E6> Tj 1 0 0 1 302.40 78.00 Tm <82A4> Tj 1 0 0 1 308.88 78.48 Tm <82C9> Tj 0.00 Tc 1 0 0 1 316.08 77.52 Tm <2C20> Tj 7.68 Tc 1 0 0 1 324.96 78.72 Tm <8369> Tj 1 0 0 1 333.60 78.48 Tm <8343> Tj 1 0 0 1 342.48 78.96 Tm <8374> Tj 1 0 0 1 349.68 78.48 Tm <82C5> Tj 1 0 0 1 358.56 78.72 Tm <834A> Tj 1 0 0 1 366.48 78.96 Tm <8376> Tj 1 0 0 1 373.92 79.20 Tm <835A> Tj 1 0 0 1 382.08 79.20 Tm <838B> Tj 1 0 0 1 390.48 78.00 Tm <82F0> Tj 1 0 0 1 401.28 78.72 Tm <8367> Tj 1 0 0 1 408.96 79.20 Tm <838C> Tj 1 0 0 1 417.12 78.96 Tm <8374> Tj 1 0 0 1 425.28 78.72 Tm <8342> Tj 1 0 0 1 432.48 79.20 Tm <8393> Tj 1 0 0 1 439.92 78.48 Tm <82CC> Tj 1 0 0 1 447.36 77.76 Tm <8C60> Tj 1 0 0 1 456.00 78.48 Tm <82C9> Tj 1 0 0 1 284.64 66.48 Tm <90D8> Tj 1 0 0 1 293.28 66.96 Tm <82C1> Tj 1 0 0 1 300.24 67.20 Tm <82C4> Tj 1 0 0 1 307.68 67.20 Tm <82A9> Tj 1 0 0 1 316.32 66.72 Tm <82E7> Tj 1 0 0 1 323.04 66.48 Tm <91C5> Tj 1 0 0 1 331.92 66.96 Tm <82BF> Tj 1 0 0 1 339.36 66.48 Tm <94B2> Tj 1 0 0 1 347.76 67.44 Tm <82A2> Tj 1 0 0 1 355.44 66.96 Tm <82C4> Tj 1 0 0 1 363.12 67.44 Tm <82A2> Tj 1 0 0 1 371.04 66.96 Tm <82E9> Tj 1 0 0 1 377.52 66.24 Tm <8142> Tj ET endstream endobj 5 0 obj <>stream 日眼会誌 95巻 6号 in the equatorial portion than in the central portion. Nevertheless the activity of GST in humancataractous lenses decreased more significantly in the peripheral portion than in the central portion.These findings indicated that the human cataract usually develop from equatorial portion of lens.(Acta Soc Ophthalmol Jpn 95:591-594, 1991) Key words: Human cataractous lens, Glutathione-S-transferase, Glutathione, Radical scavengingsystem I緒 言 水晶体に於ける異物代謝機構を調べる事は,自内障発生機序の研究を行う場合重要な課題となっている.とくに還元型グルタチオンを高濃度で合有する水晶体には,異物代謝機構のinitiatorとしてglutathione‐S―transたrase〔EC 2.5.1.18〕(以下GSTと略す)が存在し,他の酵素に対する活性比率が他の臓器に比して高いことが報告されている。.又,一般に自内障眼ではGST活性が低下していると言われている2)3).そしてGSTのisozymeの一部はselenium in‐dependent glutathione peroxidase活性も持っているとされており4),活性酸素の除去にも重要な役割を演じているためにGSTは自内障発生防御酵素として注目を浴びている酵素でもある。このため多数の研究報告がなされてきている1").ところで,老人性自内障の発生原因として多数の要因が上げられてきたが,眼組織は他の組織と異なり,光エネルギーが侵入する組織であるため,眼病変の病態を考える上で,光の影響を考慮に入れる必要がある.特に自内障発症要因の一つとして紫外線,及び近紫外線の影響は活性酸素の発生と絡み,無視できないとされてきた。そこで本研究においてはヒト水晶体を光が通過する中心部と虹彩に隠されている周辺部に分割して白内障発症防御因子の一つであるGSTについて活性を測定し,老人性白内障水晶体と透明水晶体との比較検討をした。II 実験方法 試料として,全摘された糖尿病を合併していない43歳から82歳までの後嚢下混濁を主体とした老人性自内障水晶体15例と,脱臼水晶体,及び摘出眼球より得られた透明水晶体8例を用いた。これらの水晶体は可及的に,虹彩色素を取り除き使用まで-20℃に保存されたものを使用した。方法として,水晶体をガラス板に置き固定し直径6 mmのパンチャーを当て,剃刀でそれに添って水晶体嚢を切開したのち,図1に示すように核と皮質をそのまま打ち抜き,またその下の水晶体嚢を剃刀で切開し,完全に分割して,水晶体を中心部と周辺部の二つのブロックとした。分割した水晶体を50mM,pH 7.8のphOsphate buffer 2rnl‐て}hon■ogenizeしたの)ち4℃12,000rpmにて30分間遠心し,その上清を水晶体中のグルタチオンや他の低分子還元物質を除くためcentricon B(Amicon社製)を用いて, 2倍に濃縮したものを用いた。GST活性測定はHabigら7)の方法に依り,1‐chloro‐2,4-dinitrobenzenを基質としてGSTの活性値を測定した。蛋白定量はBradford法に従った。活性値は可溶性蛋白mgあたりの吸光度(340nm)の変化を国際単位(mU)で表わした。 III 結 果 老人性白内障水晶体15例,及び透明水晶体8例の中心部と周辺部のGST活性を測定した結果を表1に示す.透明水晶体のGST活性は中心部(C)では,8.54士4.03(mU/mg protein)であり,周辺部(P)では,19.73±6.57(mU/mg protein)であった。 それぞ`れをhomogenize図1 <水晶体の打ち抜き法>.水晶体をトレフィンで打ち抜くとき,水晶体のカプセルが巻き込まれないように, ナイフでカプセルをトレフィンの形に切ってから打ち抜いている。 endstream endobj 6 0 obj <>stream リ JFIF ロ C #*%,+)%((.4B8.1?2((:N:?DGJKJ-7QWQHVBIJGロ C ""G0(0GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGタ g ト ト オ } !1AQa"q2¢。#BアチRム$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyzヤ炎駐舶沫劒「」、・ヲァィゥェイウエオカキクケコツテトナニヌネノハメモヤユヨラリルレ矮聿褂鉅鳰ト ト オ w !1AQaq"2B贈アチ #3Rbrム $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyzcу炎駐舶沫劒「」、・ヲァィゥェイウエオカキクケコツテトナニヌネノハメモヤユヨラリルレ粤蒟跚韜レ ? =bム将滄RYz ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( (